| 可溶性血管内皮生长因子1、AT1-AA与子痫前期 |
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| 引用本文： | 邱中原,胡继芬. 可溶性血管内皮生长因子1、AT1-AA与子痫前期[J]. 国外医学:妇产科学分册, 2009, 0(3): 248-250 |
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| 作者姓名： | 邱中原 胡继芬 |
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| 作者单位： | 福建医科大学附属第一医院妇产科,福州350005 |
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| 摘 要： | 子痫前期的病理机制目前仍未完全清楚。子痫前期患者体内高水平的可溶性血管内皮生长因子1（sFlt-1）直接损伤血管内皮细胞，阻断血管生长，引起临床症状，可作为预测指标。抗血管紧张素Ⅱ1型受体自身抗体（ATI—AA）通过与受体结合，引起受体结构改变，产生病理性的细胞内信号，引起子痫前期。sFlt-1过量表达和AT1-AA的产生可能存在相关性，二者互相影响，共同参与子痫前期的病理生理过程。
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| 关 键 词： | 子痫前期 sFlt-1 血管紧张素Ⅱ 自身抗体 信号转导 |
Soluble Fms-Like Tyrosine Kinase-1 and Agonistic Autoantibody to the Angiotensin II Type 1 Receptor's Relationship with Preeclampsia |
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| QIU Zhong-yuan,HU Ji-fen. Soluble Fms-Like Tyrosine Kinase-1 and Agonistic Autoantibody to the Angiotensin II Type 1 Receptor's Relationship with Preeclampsia[J]. Foreign Medical Sciences(Obstet Gynecol Fascicle), 2009, 0(3): 248-250 |
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| Authors: | QIU Zhong-yuan HU Ji-fen |
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| Affiliation: | QIU Zhong-yuan,HU Ji-fen.Department of Obstetrics and Gynecology,the First Affiliated Hospital of Fujian Medical University,Fuzhou 350005,China |
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| Abstract: | The etiology and pathogenesis of preeclampsia is still poorly understood. In preeclamptic patients, excessively high soluble fms-like tyrosine kinase 1 (sFlt-1) concertrations which is directly to endothelial dysfunction,anti -angiogenic and clinical symptoms,could be a predictor. Pathological intracellular signaling which contribute to preeclampsia is produced via Agonistic Angiotensin II Type 1 Receptor Autoantibodies (AT1-AA)binding to AT1 receptor and alter the conformation of the receptor. There maybe ... |
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| Keywords: | Preeclampsia sFlt-1 AngiotensinII Autoantibody Signal Transduction |
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