| C—erbB—2和组织蛋白酶D在食管癌中的表达及相关性研究 |
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| 引用本文： | 谷化平,李全华.C—erbB—2和组织蛋白酶D在食管癌中的表达及相关性研究[J].河北医学,2000,6(1):5-7. |
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| 作者姓名： | 谷化平 李全华 |
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| 作者单位： | 河北省张家口解放军251医院!河北张家口075000(谷化平，尚培中，苏红)，上海第二军医大学长海医院病理科!上海200050(李全华) |
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| 摘 要： | 目的：研究Ｃ－ｅｒｂＢ－２和组织蛋白酶Ｄ（Ｃａｔｈ－Ｄ）表达与食管癌分级、浸润、转移和预后的关系，以及ＣｅｒｂｂＢ－２表达与Ｃａｔｈ－Ｄ表达的相互关系。方法：应用微波－ＳＰ免疫组化法：检测６５例食管鳞状细胞癌组织中Ｃ－ｅｒｂＢ－２和ＰＣＡＮ表达水平。结果：在食管癌中Ｃ－ｅｒｂＢ－２和Ｃａｔｈ－Ｄ表达阳性率分别为５０．８％和６４．６％。ＣｅｒｂＢ－２和Ｃａｔｈ－Ｄ表达与肿瘤分级、浸润、淋巴结转移和预
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| 关 键 词： | 食管肿瘤 C－erbB－2蛋白 组织蛋白酶D |
A study on the association of C-erbB-2 protein cathepsin D expression in esophageal carcinoma |
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| GU Hua ping ,SHANG Pei zhong ,LI Quan hua ,SU Hong.A study on the association of C-erbB-2 protein cathepsin D expression in esophageal carcinoma[J].Hebei Medicine,2000,6(1):5-7. |
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| Authors: | GU Hua ping SHANG Pei zhong LI Quan hua SU Hong |
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| Institution: | GU Hua ping 1,SHANG Pei zhong 1,LI Quan hua 2,SU Hong 1 |
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| Abstract: | Objective:To study the association of C erbB 2 expression with cathepsin D(Cath D) in esophageal carcinoma.Methods:Microwave LSAB immunohistochemical method was used to examine the expression of C erbB 2 protein and Cath D in 65 specimens of esophageal carcinoma.Results:The positive rates of C erbB 2 protein and Cath D was 50.8% and 64.6% respectively.The expression of C erbB 2 protein and Cath D in squamous carcinoma were correlated with tumor grade,infitration,lymph nodes metastasis and prognosis.The expression of C erbB 2 was positively correlated with the expression of and Cath D (r=0.42,P<0.005).Conclusion:C erbB 2 protein and Cath D expression is important to determine the degree of malignacy and prognosis,and predict lymph node metastasis of esophageal carcinoma.There might be regulated interaction between C erbB 2 protein and Cath D. |
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| Keywords: | Esophageal neoplasms Squamous carcinoma C erbB 2 protein Cathepsin D Immunohistochemistry |
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