| 增生性瘢痕中TGF—β和胶原酶,TIMP—1 mRNA表达的定量研究 |
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| 引用本文： | 武继祥,陈德英.增生性瘢痕中TGF—β和胶原酶,TIMP—1 mRNA表达的定量研究[J].中华整形外科杂志,2000,16(1):34-36. |
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| 作者姓名： | 武继祥 陈德英 |
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| 作者单位： | [1]第三军医大学西南医院康复理疗科 [2]第三军医大学组织胚胎教研室 |
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| 摘 要： | 目的 观察ＴＧＦ－β和胶原酶、ＴＩＭＰ－１ ｍＲＮＡ在增生性瘢痕中的表达，探讨ＴＧＦ－β对ＭＭＰ－１和ＴＩＭＰ－１表达的影响以及它们在ＨＴＳ形成中的作用。方法 采用原位杂交和图像分析技术，进行定性和定量分析。结果 增生性瘢痕组织中ＴＧＦ－β和ＴＩＭＰ－１表达较正常皮肤明显增高，平均积分光密度分别增加了８倍和７倍，产较胶原酶的表达明显增高，相关非常显著，ＴＧＦ－β表达与ＴＩＭＰ－１表达呈高度正相关。
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| 关 键 词： | 瘢痕 转化生长因子 胶原酶 TIMP－1 mRNA |
Quantitative study on the expression of mRNA for TGF-beta and collagenase (MMP-1), tissue metalloproteinase inhibitor-1 (TIMP-1) in hypertrophic scar] |
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| J Wu,D Chen,Z Wu.Quantitative study on the expression of mRNA for TGF-beta and collagenase (MMP-1), tissue metalloproteinase inhibitor-1 (TIMP-1) in hypertrophic scar][J].Chinese Journal of Plastic Surgery,2000,16(1):34-36. |
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| Authors: | J Wu D Chen Z Wu |
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| Institution: | Department of Physical Medicine and Rehabilitation, Southwest Hospital, Third Military Medical University, Chongqing 400038, PR China. |
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| Abstract: | OBJECTIVE: To investigate the expression of mRNA for TGF-beta, MMP-1 and TIMP-1 and their effects on the formation of hypertrophic scar (HTS). METHODS: In situ hybridization and image analysis were used in this study. RESULTS: The expressions of mRNA for TGF-beta and TIMP-1 in HTS was greatly increased compared with those of normal skin. The average integral optical density of mRNA for TGF-beta and TIMP-1 increased by 8 and 7 folds (P < 0.001) related to normal skin and the expression of them showed highly positive correlation. CONCLUSIONS: The findings suggest that TGF-beta promotes the expression of TIMP-1 and may be a possible factor for hypertrophic scar formation. |
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