Nicotine reinforcement in rats with histories of cocaine self-administration |
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| Authors: | M Tessari E Valerio C Chiamulera P M Beardsley |
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| Institution: | (1) Glaxo Research Laboratories, via Fleming 2, I-37100 Verona, Italy;(2) Present address: Department of Pharmacology and Toxicology, Medical College of Virginia, PO Box 613, 23298-0613 Richmond, VA, USA |
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| Abstract: | Few reports have described conditions under which nicotine self-administration occurs in rats. In this study, rats which initially lever pressed for cocaine infusion (0.05 mg/kg) during 1 h experimental sessions continued to obtain similar infusion numbers when nicotine (0.03 mg/kg) was available. When saline was substituted for nicotine, infusions decreased from 11.8±4.5/h to 5.4±1.1/h but returned to pre-saline levels when it was reintroduced (12.0±5.5/h). These results indicate that nicotine can serve as a positive reinforcer for rats under the historical and schedule conditions described. |
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| Keywords: | Nicotine Cocaine Self-administration Reinforcement Rat |
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