| 两种老年性皮肤肿瘤Dsg1和E-cad的表达 |
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| 引用本文： | 葛新红,张进才,涂平,韩纲文,朱学俊. 两种老年性皮肤肿瘤Dsg1和E-cad的表达[J]. 宁夏医学杂志, 2006, 28(5): 362-363 |
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| 作者姓名： | 葛新红 张进才 涂平 韩纲文 朱学俊 |
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| 作者单位： | 宁夏医学院附属医院,宁夏,银川,750004;北京大学第一医院,北京,100034 |
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| 摘 要： | 目的比较两种老年人常见的皮肤肿瘤—鳞状细胞癌(BCC)与基底细胞癌(SCC)的生物学行为的异同。方法用免疫组化方法检测了26例SCC、30例BCC及10例正常皮肤组织中桥粒芯糖蛋白1(Dsg1)和E-钙黏着蛋白(E-cad)的表达。结果Dsg1在BCC和SCC中的表达均显著减弱或完全消失;E-cad在SCC中的表达显著减弱,而在BCC中的表达却为阳性。结论BCC和SCC侵袭性生长的特性与Dsg1的低表达有关,SCC易发生转移的特性与E-cad的低表达有关。
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| 关 键 词： | 桥粒芯糖蛋白1 E-钙黏着蛋白 免疫组化 鳞状细胞癌 基底细胞癌 |
| 文章编号： | 1001-5949(2006)05-0362-02 |
| 收稿时间： | 2005-12-21 |
| 修稿时间： | 2005-12-21 |
The immunohistochemistry study of two kinds of elders,skin carcinoma |
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| GE Xin - hong,et al.. The immunohistochemistry study of two kinds of elders,skin carcinoma[J]. Ningxia Medical Journal, 2006, 28(5): 362-363 |
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| Authors: | GE Xin - hong et al. |
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| Affiliation: | The Affiliated Hosp. of Ningxia Med. Coll., Yinchuan 750004, China |
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| Abstract: | Objective To evaluate the difference of the clinical,biological and histopathological features in two kinds of elders,skin carcinoma BCC and SCC.Methods We investigated desmoglein1 and E-cadherin expression in 26 SCC and 30 BCC with monoclonal antibodies to desmoglein1 and E-cadherin used immunohistochemistry staining.Results In SCC the expression of desmoglein1 and E-cadherin markedly reduced or absent in tumor cells.In BCC the expression of desmoglein1 markedly reduced or absent in tumor cells also,but E-cadherin was strongly expressed.Conclusion These results suggest the reduction or absence of desmoglein1 expression may be related to invasiveness of skin carcinomas,the reduction or absence of E-cadherin expression may be related to the metastasis of SCC. |
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| Keywords: | Desmoglein1 E-cadherin Immunohistochemistry Squamous cell carcinoma Basal cell carcinoma |
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