| NRF2与MRP2在原发性胆囊癌中的表达 |
| |
| 引用本文： | 张明鑫,蔡惠,王健生,叶尔买克,张佳,段小艺,石景森.NRF2与MRP2在原发性胆囊癌中的表达[J].中华肝胆外科杂志,2010,17(12):299-301. |
| |
| 作者姓名： | 张明鑫 蔡惠 王健生 叶尔买克 张佳 段小艺 石景森 |
| |
| 作者单位： | 西安交通大学医学院第一附属医院肿瘤外科,710061;核医学科,西安交通大学医学院第一附属医院,710061; |
| |
| 基金项目： | 本课题受国家自然科学基金资助项目资助 |
| |
| 摘 要： | Objective To detect the expressions of Nuclear factor-erythroid 2 p45-related factor 2 (NRF2) and multidrug resistance-associated protein 2 (MRP2), and investigate their significance in primary gallbladder carcinoma. Methods Immunohistochemistry SP assay and image analysis were used to detect the expressions of NRF2 and MRP2 protein in 59 patients with primary gallbladder carcinoma. Results A highly positive expression rates of NRF2 and MRP2 were found (76.3% and 74. 6%, respectively) in primary gallbladder carcinoma. The expressions of NRF2 and MRP2 had a significantly correlation with metastases, Nevin staging, and differentiation (P＜0.05), but there was no statistical association with sex and age. The expression of NRF2 had a positive correlation with MRP2 (r=0. 589,P＜0.05). Conclusion Both NRF2 and MRP2 were overexpressed in primary gallbladder carcinoma and they may play a role in the development of primary gallbladder carcinoma.
|
| 关 键 词： | 核因子E2 p45相关因子2 多药耐药相关蛋白2 原发性胆囊癌 免疫组织化学 |
The expressions of NRF2 and MRP2 in primary gallbladder carcinoma |
| |
| ZHANG Ming-xin,CAI Hui,WANG Jian-sheng,YEER Mai-ke,ZHANG Jia,DUAN Xiao-yi,SHI Jing-sen.The expressions of NRF2 and MRP2 in primary gallbladder carcinoma[J].Chinese Journal of Hepatobiliary Surgery,2010,17(12):299-301. |
| |
| Authors: | ZHANG Ming-xin CAI Hui WANG Jian-sheng YEER Mai-ke ZHANG Jia DUAN Xiao-yi SHI Jing-sen |
| |
| Abstract: | |
| |
| Keywords: | Nuclear factor-erythroid 2 p45-related factor 2Multidrug resistance-associated protein 2Primary gallbladder carcinomaImmunohistochemistry |
|
|
