具有暴力行为的精神分裂症患者病情缓解阶段事件相关电位N270的变化

Objective To explore the cognitive impairments of schizophrenia patients with violence (Sch) in remission and to verify the feasibility of N270 as a clinical examination method to evaluate the cognitive state of schizophrenic patients.Methods Stimulus pairs with identical (match condition) or different (conflict condition) colors were randomly presented to all subjects.Twenty-four Sch patients and twenty-five age-matched normal controls ( NC ) determined if the two stimuli in a pair had the same color while ERPs were recorded from their scalps, using EGI (Electrical Geodesics Inc., Eugene, OR) 256 high density EEG.Results (1) No significant difference on reaction accuracy were found between Sch and NC groups regardless of identical or different colors ( P ＞ 0.05 ), and Sch group showed more delayed reaction time than NC group [identical: Sch(774.17 ± 231.25 ) ms, NC (642.28 ± 185.56 ) ms, t = 2.206, P =0.032; different: Sch(835.35 ±246.79) ms, NC (681.19±207.87) ms, t =2.369, P =0.022].Reaction time under condition of different color was longer than that of identical color in Sch and NC groups (P ＜0.05).(2) Sch group showed more delayed N270 latency and decreased N270 amplitude than NC group (P ＜ 0.05) at F3, F4, C3, C4, Fz, Cz sites.(3) Sch group showed more decreased amplitude of N270 difference wave than NC group at F3, F4, C3,Fz, Cz sites( P ＜0.05), and more delayed latency of N270 difference wave than NC group at F3, F4, C3, C4, Fz, Cz sites ( P ＜ 0.05 ).Conclusions Schizophrenia patients with violence in remission show cognitive deficits, N270 is probably an effective index to detect the cognitive impairment in schizophrenic patients.

Event-related potential N270 in remitted schizophrenia patients with violence behavior