光敏灭菌辅助龈下刮治后不同深度牙周袋的恢复率比较研究

目的评价PERIOWAVETM光敏灭菌法治疗慢性牙周炎后≥4mm牙周袋的恢复效果。方法经伦理委员会同意后,选择45例患者(每位患者口腔内至少有4个以上≥5mm的牙周袋并分布在2个以上口腔区域内),在接受基础检查以及根面平整术(SRP)治疗后,随机分入3组,A组在SRP之后接受1次PERIOWAVETM光敏灭菌治疗,B组在SRP后及6周后各接受1次PERIOWAVETM治疗,而C组仅接受SRP治疗。在基础检查及12周后测量牙周袋深度。结果在基础检查中共有1851个≥5mm牙周袋,经过治疗后,C组有212(36.7%)个牙周袋≤3mm,A组有160(62.5%)个牙周袋≤3mm,而B组有187(84.6%)个牙周袋≤3mm;705个4mm的牙周袋,治疗后PD≤3mm的C组147(66.5%)个,A组160(62.5%)个,B组187(84.6%)个。经两样本二项分布检验,对于基础检查中为测量为4mm及≥5mm牙周袋,B组的恢复均明显好于A组及C组(P<0.0001)。结论在SRP基础上加以2次光敏灭菌治疗牙周炎对于浅(4mm)及深(≥5mm)牙周袋深度的恢复均明显大于单独使用SRP。

Comparative recovery study of periodontal pockets of different depths with new photodynamic treatment

Objective To determine full recovery rates(improvement to ≤3 mm)of ≥4 mm periodontal pockets treated with a new photodynamic treatment in a randomized and blinded clinical trial.Methods With Ethics Committee approval,45 subjects each with ≥4 sites of periodontal pocket depth(PD)≥5 mm in ≥2 quadrants] were enrolled in the study.After baseline examination,all subjects received scaling and root planing(SRP)and were then randomly assigned to one of three groups.Group A received one Periowave photodynamic treatment(Ondine Biopharma Corp.,Vancouver,BC)after SRP,while Group B received one Periowave treatment after SRP and then another 6 weeks later.Group C received SRP alone to serve as the control.PD was measured at baseline and 12 weeks.Results Totally,1,851 sites with PD ≥5mm were present at baseline.After treatment,212(36.7%)sites in Group C showed a PD ≤3 mm.In Group A,214(37.2%)sites fully recovered to a PD ≤3 mm.In Group B,389(55.7%)sites showed full recovery to a PD ≤3 mm.For 4 mm PD,705 sites were present at baseline.Post-treatment examination found that 147(66.5%)sites in Group C recovered to a PD ≤3 mm.In Group A,160(62.5%)sites recovered to a PD of ≤3 mm,while in Group B,187(84.6%)sites fully recovered to a PD of ≤3 mm.Data analysis using the normal approximation to a two-sample binomial test demonstrated that,for both PD sites at 4 mm and ≥5 mm at baseline,the recovery rates in Group B were significantly higher(P<0.0001)than those in Groups A and C.Conclusion Under conditions of this study,two photodynamic treatments after SRP significantly increased full recovery rates in both shallow(4 mm)and deep(≥5 mm)periodontal pockets,compared with SRP alone for periodontal disease therapy.