| 凝血纤溶失衡及炎性因子与冠状动脉粥样硬化性心脏病的关系研究进展 |
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| 引用本文： | 林志,张戈,孙林. 凝血纤溶失衡及炎性因子与冠状动脉粥样硬化性心脏病的关系研究进展[J]. 医学综述, 2008, 14(24): 3685-3687 |
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| 作者姓名： | 林志 张戈 孙林 |
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| 作者单位： | 昆明医学院第二附属医院心内科,昆明,650101 |
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| 基金项目： | 云南省科技厅-昆明医学院应用基础研究联合专项资金项目 |
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| 摘 要： | 纤溶酶原激活物抑制物1(PAI-1)是调节血浆纤溶活性的关键因素。PAI-1水平升高导致纤维蛋白降解减少,从而引起血浆纤维蛋白原水平升高,血液呈高凝状态,有利于血栓形成。同时,炎性反应导致血管内皮受损,参与血栓形成。PAI-1、纤维蛋白原和炎性因子如白细胞介素6、肿瘤坏死因子α不仅在冠状动脉粥样硬化性心脏病的发病机制中发挥着重要作用,而且与冠状动脉粥样硬化性心脏病的预后有关。
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| 关 键 词： | 冠状动脉粥样硬化性心脏病 纤溶酶原激活物抑制物1 纤维蛋白原 白细胞介素6 肿瘤坏死因子α |
Progresses about Relationship of Atherosclerotic Heart Disease with Imbanlance Between Coagulation and Fibrinolysis and Inflammatory |
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| LIN Zhi,ZHANG Ge,SUN Lin. Progresses about Relationship of Atherosclerotic Heart Disease with Imbanlance Between Coagulation and Fibrinolysis and Inflammatory[J]. Medical Recapitulate, 2008, 14(24): 3685-3687 |
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| Authors: | LIN Zhi ZHANG Ge SUN Lin |
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| Affiliation: | Department of Cardiology;Second Affiliated Hospital of Kunming Medical College;Kunming 650101;China |
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| Abstract: | The plasminogen activator inhibitor-1 is the main factor determining the plasma fibrinolytic activity.The elevated plasminogen activator inhibitor-1 impedes the decomposition of fibrin,and then result in the increased plasma fibrinogen.The high level of fibrinogen leads to the hypercoagulabale state and accelerates the thrombosis.At the same time,the impaired endothelium resulting from inflammatory also attends the thrombogenesis.Many factors,for example plasminogen activator inhibitor-1,fibrinogen and infl... |
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| Keywords: | Coronary heart disease Plasminogen activator inhibitor-1 Fibrinogen Interleukin-6 Tumor necrosis factor-alpha |
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