动脉灌注化疗对局部晚期鼻咽癌的近期疗效 |
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引用本文: | 陈建武,张幸平,刘德鑫,肖丽华,吴敏,苏菁菁,郑建清. 动脉灌注化疗对局部晚期鼻咽癌的近期疗效[J]. 安徽医科大学学报, 2015, 0(11) |
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作者姓名: | 陈建武 张幸平 刘德鑫 肖丽华 吴敏 苏菁菁 郑建清 |
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作者单位: | 1. 福建医科大学附属第二医院放疗科,泉州,362000;2. 重庆医科大学附属第一医院肿瘤科,重庆,400016;3. 福建医科大学附属第二医院放射科,泉州,362000 |
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基金项目: | 福建省自然科学基金(编号2011J01155);福建省医学创新课题(编号2009cx-10) |
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摘 要: | 将局部晚期鼻咽癌患者分为动脉灌注化疗联合放疗(IAC)组和静脉诱导化疗联合放疗(IVC)组。治疗后4周, IAC 组与 IVC 组的完全缓解(CR)率分别为94.0%、70.0%,差异有统计学意义(P <0.05);治疗后12周,IAC 组与 IVC组的 CR 率分别为98.0%、72.0%,差异有统计学意义(P <0.05)。两组治疗有效率均为100%,均未发现远处转移病例。两组之间3、4级急性毒副反应发生率比较,差异无统计学意义(P >0.05)。因此动脉灌注诱导化疗联合后期同步放化疗疗效可靠、安全。
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关 键 词: | 动脉灌注 放化疗 局部晚期鼻咽癌 近期疗效 |
Early clinical effect of intra-arterial induction chemotherapy on Locally advanced nasopharyngeal carcinoma |
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Abstract: | LANC was randomly divided into IAC,intra-arterial neoadjuvant chemotherapy followed by concurrent chemo-radiotherapy and IVC,intravenous neoadjuvant chemotherapy combined with radiotherapy.After 4 weeks, the complete remission rate (CR)in group IAC and IVC was 94.0% vs 70.0%,with statistical significance (P <0.05),and at 12 weeks,98.0% vs 72.0%,with statistical significance (P <0.05).The effective rate of the two groups was both 100%,and there was no distant metastasis.3,4 grade of acute toxicity incidence in Group IAC and Group IVC was 32.0% and 34.0%,respectively,without statistical significance (P >0.05).Intra-arterial induction chemotherapy followed by concurrent chemo-radiotherapy has obvious effect on LANC and perform safely. |
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Keywords: | intra-arterial chemotherapy radio-chemotherapy locally advanced nasopharyngeal carcinoma early clinical effect |
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