IL-12p40、IL-12p70在经典型霍奇金淋巴瘤中的表达及意义

目的 探讨白细胞介素-12p40(IL-12p40)、白细胞介素-12p70(IL-12p70)在经典型霍奇金淋巴瘤(CHL)组织中的表达及意义. 方法 应用免疫组织化学法检测IL-12p40、IL-12p70在41 例CHL组织、92 例弥漫性大B细胞淋巴瘤(DLBCL)组织及20 例反应性淋巴组织增生(RLH)中的表达. 结果 IL-12p40、IL-12p70在41例CHL及92例DLBCL中的阳性表达率分别是 51. 22%、70. 73% 及 0. 00%、4. 35%,20 例 RLH 中未见 IL-12p40 及 IL-12p70 表达. IL-12p40、IL-12p70在CHL 中及各亚型中的表达均明显高于DLBCL及RLH(P<0. 05). IL-12p40及IL-12p70的表达与患者性别、年龄、肿块大小、B症状、临床分期、血清乳酸脱氢酶水平、国际预后评分等临床病理因素均无关. IL-12p40与IL-12p70在CHL中的表达有相关性(P<0. 05). 结论 IL-12p40、IL-12p70在CHL发病中有重要作用.

Expression and significance of IL-12 p40 and IL-12 p70 in classical Hodgkin lymphoma

Objective To investigate the expression and clinical significance of interleukin-12 p40 ( IL-12 p40 ) and interleukin-12p70(IL-12p70) in patients with classical Hodgkin lymphoma (CHL). Methods IL-12p40 and IL-12p70 were stained by immunohistochemical EnVision two-step method in 41 cases of CHL, 92 cases of DLBCL and 20 cases of reactive lymphoid hyperplasia (RLH). Results The positive rates of IL-12p40 and IL-12p70 were 51. 22%, 70. 73% in CHL and 0. 00%, 4. 35% in DLBCL, no expression of IL-12 was observed in RLH. The ex-pression rates of IL-12 p40 and IL-12 p70 in CHL were significantly higher than that in DLBCL and RLH ( P <0. 05). There was no significant correlation between IL-12p40 and IL-12p70 with sex, age, bulky disease, B symptom, clinic stage, serum LDH level, and international prognostic score. IL-12p40 was positively correlated with the expression of IL-12 p70 in CHL ( P <0. 05 ) . Conclusion The IL-12 p40 and IL-12 p70 play important roles in the pathogenesis of CHL.