337例胎儿超声软指标阳性染色体结果分析

目的 分析337例胎儿超声软指标( USMs)阳性的染色体结果,并探讨其与染色体异常的关系. 方法 对行产前诊断且USMs阳性的337例孕妇,统计染色体结果行回顾性分析,将研究对象分为单纯USMs阳性组( A组,186例;1项USMs阳性为A1组,150例;2项及以上USMs阳性为A2组, 36例) ,USMs阳性合并高龄或唐筛高风险组( B组,82例) , USMs阳性合并其他异常组( C组,69例) ,并分析其与染色体的联系. 结果 A1 组、A2 组染色体异常发生率比较,差异无统计学意义;A组与B组染色体异常率比较差异无统计学意义;A 组与 C 组异常率比较差异有统计学意义(P <0. 05). 结论 USMs阳性可能增加染色体异常风险,需正确评估其应用价值以减少不必要的有创产前诊断,但是合并其他结构异常,必须在染色体正常的前提下继续妊娠.

Analysis on chromosomal outcome of ultrasound soft marker of 337 fetuses

Objective To analyze the chromosome karyotype of abnormal ultrasound soft markers( USMs) and dis-cuss the relationship betweeen the USMs and chromosomal abnormality. Methods Selecting the 337 pregnant women who did the prenatal diagnosis with the USMs,recording the chromosome karyotype of fetuses and doing the retrospective study. The research subjects were divided into three groups,including the only USMs group( group A, 186 cases;containing only one USMs,group A1,150 cases;one more USMs,group A2,36 cases),the USMs merging the eldly pregnant women or high risk of Downs' screening( group B,82 cases) ,the USMs merging the other abnor-mality( group C,69 cases) ,and analyzing the relationship with chromosomal abnormality. Results The incidence of chromosomal abnormalities between A1 and A2 was not statistically significant, and the A and B were the same, however the incidence of chromosomal abnormalities between A and C was statistically significant ( P <0. 05 ) . Conclusion The USMs may improve the risk of chromosomal abnormality,assessing the practical value correctly to decline the unnecessarily invasive prenatal diagnosis. Nevertheless,USMs merging other structural abnormalities can continue the pregnancy under the condition of the normal chromosome karyotype.