骨桥蛋白表达与结直肠癌临床病理特征及预后的关系

目的 探讨骨桥蛋白( OPN)在结直肠癌组织中的表达与临床病理特征及预后的关系. 方法 应用免疫组化SP法测定112例结直肠癌患者癌组织及癌旁正常组织中OPN表达水平,分析OPN表达与结直肠癌患者临床病理特征及预后的关系. 结果 结直肠癌组织中OPN阳性表达率明显高于相应癌旁正常组织,差异有统计学意义(P<0. 05),其表达水平与肿瘤直径、分化程度、TNM分期、原发肿瘤浸润深度相关;OPN阳性表达组的无病生存时间和总体生存时间均短于阴性表达组,差异有统计学意义( P<0. 05 ). OPN的阳性表达是结直肠癌患者预后的独立影响因素. 结论结直肠癌患者癌组织中OPN呈高表达, OPN在组织中的高表达与患者的早期复发及不良预后密切相关.

Expression of osteopontin in colorectal cancer with clinical pathological characteristics and prognosis

Objective To investigate the relationship between the osteopontin ( OPN ) expression of colorectal cancer tissues with the clinical characteristics and prognosis. Methods The expressions of OPN in colorectal cancer tissues and their corresponding para-cancerous tissues from 112 cases of colorectal cancer patients were detccted by immunohistochemistry . The relationship between the expressions of OPN and the clinicopathological features in pait-ients with colorectal cancer were analyzed. Results The OPN expression of colorectal cancer tissues was signifi-cantly higher than their corresponding adjacent normal tissues, the difference was statistically significant ( P <0. 05). Its expression was significantly associated with tumor size, histological differentiation, TNM stage, tumor status. Disease-free survival, and overall survival time of OPN protein positive expression group were lower than that of the negative group, respectively, the differences were statistically significant(P<0. 05). The expression of OPN in colorectal cancer tissues was an independent prognostic factor. Conclusion The expression of OPN is sig-nificantly increased in colorectal cancer tissues, and the positive expression of OPN is associated with the prognostic of patients with colorectal cancer.