克罗恩病患者血浆中细胞间黏附分子-1和血管细胞黏附分子-1水平检测的临床意义

检测96例克罗恩病( CD)患者和48例正常对照者血浆细胞黏附分子-1 ( ICAM-1 )和血管细胞黏附分子( VCAM-1)水平,与对照组比较,CD组血浆中ICAM-1和VCAM-1水平均明显增高(P<0. 01). 按疾病严重程度分组,各组血浆中ICAM-1和VCAM-1水平比较差异均有统计学意义( P<0. 01);按临床特征分组,各组内血浆中ICAM-1 和VCAM-1水平比较差异均无统计学意义. CD患者血浆中ICAM-1和VCAM-1水平明显增高,与疾病严重程度有一定关联,与临床特征无明显关联.

Clinical significance of plasma levels of intercellular cell adhesion molecule-1 and vascular cell adhesion molecule-1 in Crohn' s disease

To evaluate the value of plasma levels of intercellular cell adhesion molecule-1 ( ICAM-1 ) and vascular cell adhesion molecule-1(VCAM-1) in Crohn's diseases (CD) patients(n=96) and control group(n=48). The results showed that plasma levels of ICAM-1 and VCAM-1 in the control group were lower than that in CD group significantly(P<0. 01). Plasma ICAM-1 and VCAM-1 concentrations of each group in active stage were signifi-cantly different between the groups ( P<0. 01 ) . CD patients were grouped according to the patient′s age and the disease extent and the disease clinical type, within group variable, plasma levels of ICAM-1 and VCAM-1 were not significantly different. ICAM-1 and VCAM-1 mediated the intestinal inflammatory processes in the pathogenesis of CD. Plasma ICAM-1 and VCAM-1 levels may be positively associated with disease classification and are not corre-lated with the patient′s age and the disease extent and the disease clinical type.