Semen Malondialdehyde and Its Correlation to Sperm Function

Objective: To determine the semen malondialdehyde (MDA) and its correlation to sperm function. Design: In addition to basic semen parameters (concentration, motility,morphology , vitality, etc. ), leukocyte concentration, sperm membrane integrity and MDA were also quantified in the semen of each patient.

Semen Malondialdehyde and Its Correlation to Sperm Function

To determine the semen malondialdehyde (MDA) and its correlation tosperm function. Design: In addition to basic semen parameters (concentration, motility,morphology, vitality, etc. ), leukocyte concentration, sperm membrane integrity and MDAwere also quantified in the semen of each patient. Setting: University-based laboratory forandrndogy. Participants: 20 cases Of fertile men and 32 cases of infertile men. Results: Inour study, MDA was significantly higher in infertile men than that in fertile men. In highleukocyte group, MDA was also significantly higher than that in low leukocyte group.When MDA increased, sperm membrane integrity and the parameters which can reflect thesperm motility, such as SVT and motility score, decreased in varying degrees. The correlation between MDA and SVT as well as, motility score is significant. We also find thatthe deformity of sperm body is significantly correlated with MDA. Conclusion: Increaseof MDA' lt may imply that mitochondria membrane is attacked by ROS and is damagedand then sperm vitality is impaired consequently.