PCNA、BCL—2在胃癌中的表达 |
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引用本文: | 刘婷,刘凤阁,张绘宇. PCNA、BCL—2在胃癌中的表达[J]. 齐齐哈尔医学院学报, 2002, 23(8): 841-842 |
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作者姓名: | 刘婷 刘凤阁 张绘宇 |
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作者单位: | 齐齐哈尔医学院病理学教研室,161042 |
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摘 要: | 目的:研究增殖细胞核抗原(简称PCNA)及Bcl-2在胃癌中的表达,探索PCNA,Bcl-2同胃癌预后的关系及对临床的意义。方法:用免疫组化S-P法,结果:PCNA和Bcl-2在胃癌中的表达与癌细胞的分化程度,浸润深度及肿瘤分期有关,与淋巴结转移的相关性不明显。结论:PCNA,Bcl-2的过量表达说明胃癌细胞增殖活跃。检测PCNA和Bcl-2更有助于了解胃癌的生物学行为及预测患者的预后。
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关 键 词: | PCNA Bcl-2基因 胃癌 预后 增殖细胞核抗原 基因表达 免疫组织化学 |
The Expression Of PCNA And Bcl-2 In Gastric Cacinoma |
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Abstract: | Objective To study the expression of PCNA and Bcl-2 in gastric carcinoma and to assess the relationship between PCNA,Bcl-2 and prognosis of gastric carcinoma .Methods We used S-P Immunohistochemical method. Results The expression of PCNA and Bcl-2 in gastric carcinoma has relationship with malignant degree,invasive depth and clinical stage of carcinoma cell.It has no relationship with lymph node metastasis. Conclusions Over-expression of PCNA and Bcl-2 suggested that gastric cacinoma cells proliferated actively, the recognization of PCNA and Bcl-2 may help us to know the biological deed of gastric cacinoma and predict the prognosis of patients. |
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Keywords: | PCNA Bcl-2 Prognosis of gastric cacinoma |
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