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Special considerations with regard to the dosage of tranexamic acid in patients with chronic renal diseases |
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| Authors: | L Andersson O Eriksson P-O Hedlund H Kjellman B Lindqvist |
| Institution: | (1) Department of Urology, Karolinska Hospital, Stockholm, Sweden;(2) Department of Medicine, University of Umeå, Umeå, Sweden;(3) Research Department, Analytical Chemistry and Medicine L, AB Kabi, Stockholm, Sweden;(4) Urologkliniken Karolinska Sjukhuset, S-104 01 Stockholm, Sweden |
| Abstract: | Summary Tranexamic acid is a potent antifibrinolytic drug frequently used in the treatment of haematuria and a number of other haemorrhagic conditions. Since it is eliminated mainly in the urine, the drug accumulates in patients with uraemia. The excretion of tranexamic acid in patients with renal failure has been investigated and dosage recommendations are given for tranexamic acid therapy in cases of renal failure. |
| Keywords: | Tranexamic acid Pharmacokinetics Uraemia Impaired renal function |
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