Multiple primary squamous cell carcinomas in the upper digestive tract |
| |
| Authors: | P J Fitzpatrick B S Tepperman G deBoer |
| |
| Affiliation: | 1. Associate Professor of Radiology, University of Toronto; Radiation Oncologist, Princess Margaret Hospital, Canada;2. Resident, Ridiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Canada;3. Assistance Professor, Department of Medical Biophysics, University of Toronto; Department of Biostatistics, Princess Margaret Hospital, Canada |
| |
| Abstract: | Multiple squamous cell carcinomas are common and patients carry a constant and excessive risk of developing a new cancer at any time (13-21 X the normal). Among 6,203 cases of primary squamous carcinoma of the upper digestive tract, 648 patients (10.4%) developed two or more independent tumors. Altogether, 761 additional malignancies were observed, with up to five cancers being seen in individual patients. There were 279 patients with a prior or synchronous cancer and 409 patients who developed 462 metachronous tumors. There was a substantial risk for developing a second primary cancer in the upper aerodigestive tract. Overall the observed to expected ratio was 2.48, specifically 2.32 for males and 2.89 for females. |
| |
| Keywords: | Multiple primary neoplasms Squamous cell carcinoma Head and neck cancer Upper digestive tract |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
