原发性胆汁性肝硬化患者临床与病理学特点

目的:探讨不同程度的原发性胆汁性肝硬化(PBC)患者临床与病理特点.方法:根据PBC患者是否已进展至肝硬化将患者分为慢性胆管炎组(CC)和肝硬化组(LC),比较两组患者生化指标、肝脏组织学变化及临床并发症的差异,所有患者均给予熊去氧胆酸(UDCA)治疗,观察患者1年转归情况.结果:CC组患者病理损伤轻,对治疗敏感,LC组患者病理损伤重,治疗效果差,易出现进行性升高性黄疸、慢性肝功能衰竭.结论:PBC患者早期使用UDCA治疗有助于控制病情进展,当本病进展至肝硬化期则预后不良.

Clinical and pathology analysis of patients with primary biliary cirrhosis

Objective:To explore the clinical and pathological traits of primary biliary cirrhosis(PBC) in different stage.Methods: Patients of PBC in the hospital were divided two groups by which were companied with chronic cholangtitis(CC) or not liver cirrhosis(LC).To compare with the biochemical and pathological index,complications in the different stage.After 1 year Ursodeoxycholic Acid(UDCA) was given,the prognosis of these patients were observed.Results: The pathological injury of CC group was less than the LC group,better to treatment.The mostly patients in LC group inclined to higher jaundice and chronic liver failure.Conclusion:Early treatment of UDCA is avail to ease the disease,but PBC with cirrhosis would be worse and have poor prognosis.