DNA amplification of HIV-1 in seropositive individuals and in seronegative at-risk individuals |
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| Authors: | M Mariotti J J Lefrère B Noel F Ferrer-Le-Coeur D Vittecoq R Girot C Bosser A M Couroucé C Salmon P Rouger |
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| Affiliation: | Institut National de Transfusion Sanguine, Université Pierre et Marie Curie, Paris, France. |
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| Abstract: | We assessed the HIV-1 status of seropositive and seronegative at-risk individuals by the polymerase chain reaction. Fifty-four out of 55 HIV-1-seropositive samples scored positive. However, HIV-1 proviral DNA was not detected in 16 seronegative homosexuals, 20 seronegative polytransfused haemophiliacs and 20 seronegative thalassaemic children, 20 individuals with isolated and persistent anti-core antibodies and 74 seronegative blood donors. These data indicate that positive HIV-1 DNA is likely to be an exceptional phenomenon in HIV-seronegative people. |
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