| 抑郁症患者治疗前后血浆孤啡肽的研究 |
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| 引用本文： | 张璐璐,郑洪波,马崔,何柱国,郑朝盾. 抑郁症患者治疗前后血浆孤啡肽的研究[J]. 中华精神科杂志, 2009, 42(3): 138-141. DOI: 10.3760/cma.j.issn.1006-7884.2009.03.005 |
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| 作者姓名： | 张璐璐 郑洪波 马崔 何柱国 郑朝盾 |
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| 作者单位： | 广州市精神病医院精神科,510370 |
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| 基金项目： | 广东省医学科学技术研究基金资助项目 |
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| 摘 要： | Objective To explore the changes of plasma orphanin FQ (OFQ) level in depressive patients before and after treatment. Methods The plasma OFQ levels of 38 depressive patients were determined with radioimmunoassay at baseline and after 8 week antidepressant treatment, and 32 healthy persons were examined once as controls. Results The concentrations of OFQ in patients were significantly higher at baseline than after treatent and in controls [(21.9 ± 2. 3 ) ng/L vs. ( 10. 9 ± 2. 1 ) ng/L; (21.9±2. 3) ng/L vs. (10. 2 ± 1.8 )ng/L; all P < 0. 01]. There were no significant differences in OFQ between patients after treatment and in controls. The OFQ concentration in patients at baseline was positively correlated to the scores of 24-items Hamilton Depression Scale (HAMD) (r =0. 857,P <0. 01 ), the change of OFQ concentration between baseline and after treatment was also positively correlated to the alteration of HAMD scores (r = 0. 342, P < 0. 05 ). Conclusions The results suggest that the alteration of OFQ may be involved in depression.
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| 关 键 词： | 抑郁症 血浆 孤啡肽 |
The plasma orphanin FQ in patients with depression before and after treatment |
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| Abstract: | Objective To explore the changes of plasma orphanin FQ (OFQ) level in depressive patients before and after treatment. Methods The plasma OFQ levels of 38 depressive patients were determined with radioimmunoassay at baseline and after 8 week antidepressant treatment, and 32 healthy persons were examined once as controls. Results The concentrations of OFQ in patients were significantly higher at baseline than after treatent and in controls [(21.9 ± 2. 3 ) ng/L vs. ( 10. 9 ± 2. 1 ) ng/L; (21.9±2. 3) ng/L vs. (10. 2 ± 1.8 )ng/L; all P < 0. 01]. There were no significant differences in OFQ between patients after treatment and in controls. The OFQ concentration in patients at baseline was positively correlated to the scores of 24-items Hamilton Depression Scale (HAMD) (r =0. 857,P <0. 01 ), the change of OFQ concentration between baseline and after treatment was also positively correlated to the alteration of HAMD scores (r = 0. 342, P < 0. 05 ). Conclusions The results suggest that the alteration of OFQ may be involved in depression. |
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| Keywords: | Depressive disorderPlasmaOrphanin FQ |
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