单次小剂量米非司酮用于紧急避孕的疗效观察

目的：比较米非司酮单次和两次用于紧急避孕的有效性，副反应及可接受性。方法：征集无保护性交或避孕失败后72小时内来我院就诊的健康妇女220例。采取双盲随机比较试样方法。分为Ⅰ组（n=112）和Ⅱ组（n=108）予以治疗。Ⅰ组单次服用米非司酮1片（10mg）。Ⅱ组第一次服用米非司酮一片，12小时后再服一片，总量为20mg。服药后按时随访，了解避孕效果、副反应、下次月经情况。结果：两组各发生1例妊娠，失败率分别为0．89％和0．93％，避孕有效率分别为91．09％和91．12％，P〉0．05，无统计学差异。各种副反应发生率较低，均在10％以内。月经趋于正常者分别为90％和87％，P〉0．05。结论：单次小剂量米非司酮10mg用于紧急避孕同样是安全有效的。

Single and Small dose of mifepristone for Emergency contraception of curative effect observe

Objective:To compare the efficacy, side effects and acceptobility of mifepristone only 10mg or double 10mg for emergency contraception. Methods:220health women, who were after 72 hours of unprotected intercourse coming to my hospital. We used a double-blind randomized. They were all ocated to either group1 or 2 for treatmented one group consists of 162 women anther group consists of 108 women. In group 1 mifepristone 10mg (1 tablet) was taken. In group 2 mifepristone 10mg was taken,After 12 hour mifepristone 10mg was taken again. Follow-up visit was performed on the 7 th day of next expected period of menstruation in order to evaluate the contraceptive efficacy side effects of mifepristone and the changes of menstruation. Result:In either group on women was pregnant and the failure rate of contraception by mifepristone was 0.89% and 0.93% in group 1 and 2, contraceptive rate was 91.09% in group 1 and 91.12% in group 2. There was no statiscical difference between the two groups(P>0.05), The side effects were mild, its insidence was less than 10% in eath group. Normal menstraction was 90% and 87% in group 1 and 2, P>0.05. Conclusion:It is equally effective and safe to once use little dose and of mifepristone 10mg in emergency contraception.