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| p16基因在K562/A02细胞株表达情况的研究 | |
| 引用本文： | 寿倍明,陈宝安,周冬蕊,刘德龙,丁家华,高冲,孙耘玉,王骏,程坚,赵刚,宋慧慧,鲍文,陆祖宏.p16基因在K562/A02细胞株表达情况的研究[J].东南大学学报(医学版),2008,27(3):151-153. |
| 作者姓名： | 寿倍明 陈宝安 周冬蕊 刘德龙 丁家华 高冲 孙耘玉 王骏 程坚 赵刚 宋慧慧 鲍文 陆祖宏 |
| 作者单位： | 1. 东南大学,临床医学院,江苏,南京,210009 2. 东南大学附属中大医院,血液科,江苏,南京,210009 3. 东南大学,生物科学与医学工程学院,江苏,南京,210096 4. 纽约医学院,医学部,美国,纽约,10595 |
| 摘 要： | 目的:研究p16基因在K562/A02细胞株的表达情况及其与耐药的关系。方法:用PCR法对慢性髓系白血病细胞株K562及其耐药细胞株K562/A02进行p16基因缺失检测。结果:K562及K562/A02细胞株经PCR扩增后,均未扩出相应条带。结论:K562/A02细胞株与K562细胞株一样,均表现为p16基因缺失。 |
| 关 键 词： | p16基因 K562细胞株 K562/A02细胞株 表达 缺失 |
| 文章编号： | 1671-6264(2008)03-0151-03 |
| 修稿时间： | 2007年10月30 |
Research of expression of p16 gene in K562/A02 cell line |
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| SHOU Bei-ming,CHEN Bao-an,ZHOU Dong-rui,LIU De-long,DING Jia-hua,GAO Chong,SUN Yun-yu,WANG Jun,CHENG Jian,ZHAO Gang,SONG Hui-hui,BAO Wen,LU Zu-hong.Research of expression of p16 gene in K562/A02 cell line[J].Journal of Southeast Univ: Medical Sci Ed,2008,27(3):151-153. | |
| Authors: | SHOU Bei-ming CHEN Bao-an ZHOU Dong-rui LIU De-long DING Jia-hua GAO Chong SUN Yun-yu WANG Jun CHENG Jian ZHAO Gang SONG Hui-hui BAO Wen LU Zu-hong |
| Abstract: | Objective To discuss the expression of p16 gene in K562/A02 cell line and the relationship between the expression of p16 gene and multidrug resistance.Method Polymerase chain reaction method was used to detect the expression of p16 gene.Result After PCR,both K562 and K562/A02 cell line had not been found to have amplified stripes.Conclusion Both K562 and K562/A02 cell line show deletion of p16 gene. |
| Keywords: | p16 gene K562 cell line K562/A02 cell line expression deletion |
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