|
|||||
|
|
| 血栓素合成酶抑制剂哒唑氧苯对大鼠缺血再灌注性心律失常的影响 | |
| 引用本文： | 赵仙先,章同华,秦永文,周炳炎,丁鸿钧. 血栓素合成酶抑制剂哒唑氧苯对大鼠缺血再灌注性心律失常的影响[J]. 第二军医大学学报, 1993, 0(4) |
| 作者姓名： | 赵仙先 章同华 秦永文 周炳炎 丁鸿钧 |
| 作者单位： | 长海医院心血管内科 200433(赵仙先，章同华，秦永文，周炳炎)，长海医院心血管内科 200433(丁鸿钧) |
| 摘 要： | 应用我校药学院合成的选择性血栓素含成酶抑制剂哒唑氧苯观察了其对大鼠缺血再灌注心律失常的影响,结果表明,冠状动脉结扎前15min静脉注射哒唑氧苯能明显降低大鼠再灌注性心律失常的发生率(对照组11/13,给药组4/13,P<0.01),并缩短室速和室颤的持续时间,降低心律失常平均积分(P<0.05)。提示哒唑氧苯对预防再灌注性心律失常有效。 |
| 关 键 词： | 血栓素A_2 哒唑氧苯 心肌再灌注 心律失常 动物 大鼠 |
Effects of Dazoxiben, a Selective Thromboxane Synthetase Inhibitor, on Reperfusion Arrhythmias in Rats |
|
| Zhao Xianxian,Zhang Tonghua,Qin Yongwen,Zhou Bingyan,Ding Hongjun. Effects of Dazoxiben, a Selective Thromboxane Synthetase Inhibitor, on Reperfusion Arrhythmias in Rats[J]. Former Academic Journal of Second Military Medical University, 1993, 0(4) | |
| Authors: | Zhao Xianxian Zhang Tonghua Qin Yongwen Zhou Bingyan Ding Hongjun |
| Abstract: | We studied the effects of the selective thromboxane synthetase inhibitor, dazoxiben (UK-37 248), on the reperfusion arrhythmias induced by ischemia-reperfusion in rats. The results indicated that the administration of dazoxiben (2.5 mg/kg i.v.) 15 min prior to coronary occlusion significantly decreased the incidence of ventricular fibrillation induced by 5 inin ischemia and reperfusion from 11/13 in control to 4/13 in drug-treated (P<0.01). It also showed that dazoxiben shortened the duration of ventricular fibrillation and tachycardia and reduced the score of arrhythmias (P<0.05). These results suggest that inhibition of thromboxane A2 synthesis with dazoxiben might be useful for the prevention of ischemia-Teperfusion induced ventricular arrhythmias. |
| Keywords: | thromboxane A2 dazoxiben myocardial reperfusion arrhythmia animal rats |
| 本文献已被 CNKI 等数据库收录！ | |