raf involvement in the simultaneous genetic transfer of the radioresistant and transforming phenotypes |
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| Authors: | K F Pirollo R Garner S Y Yuan L Li W A Blattner E H Chang |
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| Institution: | Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814. |
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| Abstract: | We examined a human Alu+ mouse tertiary transformant derived from a noncancerous skin fibroblast cell line which exhibits the unique characteristic of being resistant to the killing effects of ionizing radiation. This transformed cell line was found to contain activated human c-raf-1, and demonstrated an increased level of radioresistance indicating the simultaneous transfer of both the transforming and radiation-resistant phenotypes. We have also found a relationship between the presence of activated oncogenes, specifically those with serine/threonine kinase activity and the radioresistant phenotype. |
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