桂麻合方对致热家兔血浆中前列腺素E2和环磷酸腺苷含量的影响

目的：揭示桂麻合方解热作用协同、拮抗关系的存在及产生的原因。方法：以耳缘静脉注射内毒素复制家免发热模型，测量口服桂枝汤、麻黄汤及其合方后不同时间的体温采集耳缘静脉血，血液样品按环磷酸腺苷（cAMP）、前列腺素E2（PGE2）药盒要求处理。结果：家免血中的PGE2和cAMP的变化与体温变化相平行，解热作用有协同或拮抗关系的存在。结论：桂麻合方在煎煮过程中的新整合对PGE2和cAMP含量产生影响，从而使其解热作用出现协同或拮抗关系。

Gui-ma Composite Decoction''''s Effects on the cAMP and PGE2 in the Serum of Experimental Fever Rabbit

Objective:To reveal the existence of antagonistic or synergistic relationship between compositions of Ma-huang and Gui-zhi decoction and the reason.Methods:Copy the family rabbit fever model by iv endotoxin(ET),take the temperature at different time points after administering Gui-zhi decoction,Ma-huang decoction and their compositions,and then collect the vein blood,detect the cAMP and PGE_2 in sample according to the specification.Results:The changes of the levels of PGE_2 and cAMP are paralleled to the change of temperature.There exists an antagonistic of synergistic relationships in the defervescence effect.Conclusion:The new integrations produced in the process of decocting of Gui-ma composite decoctions have influences on the levels of PGE_2 and cAMP,which makes the defervescence effect produce the antagonistic or synergistic relationship.