| 颈交感神经干离断对CCl_4所致大鼠肝损伤肝功能的影响 |
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| 引用本文： | 曾议,夏锋,田峰,程龙,王曙光. 颈交感神经干离断对CCl_4所致大鼠肝损伤肝功能的影响[J]. 实用临床医药杂志, 2010, 14(13) |
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| 作者姓名： | 曾议 夏锋 田峰 程龙 王曙光 |
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| 作者单位： | 第三军医大学附属西南医院全军肝胆外科研究所、西南肝胆外科医院,重庆,400038 |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | 目的探讨大鼠颈交感神经干离断后对CCl4所致肝损伤的影响,了解交感神经对肝脏功能的调控机制。方法健康SD大鼠30只随机分为3组:A组正常对照组、B组假手术组、C组右颈交感干离断组,按照文献报道方法加以改进制作颈交感干离断模型。动物模型建立成功后,应用CCl4制作急性肝损伤模型。各组大鼠经不同处理后同一时段处死。检测各项肝功能指标及库伦阵列-高效液相色谱法测定肝组织内NE浓度。结果在CCl4所致肝损伤的情况下,颈交感神经干离断组AST、ALT、TBIL与假手术组比较显著降低(P0.05);Alb、PA较假手术组升高(P0.05)。肝组织内NE浓度较假手术组明显降低(P0.01)。结论大鼠颈交感神经干离断有利于肝脏蛋白的合成、胆红素的代谢、可减轻CCl4所致肝损伤时肝功能损害,可以减轻炎症反应。交感神经活化在炎症早期具有促炎效应。
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| 关 键 词： | 肝脏 颈交感神经离断 肝损伤 去甲肾上腺素 |
Effects of transection of cervical sympathetic trunk (TCST) on liver function in the carbon tetrachloride (CCl4)induced liver trauma of rats |
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| ZENG Yi,XIA Feng,TIAN Feng,CHENG Long,WANG Shu-guang. Effects of transection of cervical sympathetic trunk (TCST) on liver function in the carbon tetrachloride (CCl4)induced liver trauma of rats[J]. Journal of Clinical Medicine in Practice, 2010, 14(13) |
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| Authors: | ZENG Yi XIA Feng TIAN Feng CHENG Long WANG Shu-guang |
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| Affiliation: | ZENG Yi,XIA Feng,TIAN Feng,CHENG Long,WANG Shu-guang(Institute of Hepatobiliary Surgery & Southwest Hospital,Third Military Medical University,Chongqing,400038) |
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| Abstract: | Objective To observe the effects of transection of cervical sympathetic trunk(TCST) on liver function in the carbon tetrachloride(CCl4) induced liver trauma of rats.Methods Thirty healthy SD rats were divided randomly into three groups:(A)normal group,(B) shame group,(C) transection of cervical sympathetic trunk,TCST group.The transection of cervical sympathetic trunk(TCST) model was prepared by micrurgy under operating magnifier.All groups acute liver injury model was established by using CCl4.Blood chemis... |
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| Keywords: | liver TCST liver injury norepinephrine |
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