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| 燕麦β-葡聚糖对糖尿病大鼠胰岛功能的影响 | |
| 引用本文： | 汪海波,刘大川,汪海婴,崔邦梓,谢笔钧. 燕麦β-葡聚糖对糖尿病大鼠胰岛功能的影响[J]. 营养学报, 2006, 28(1): 54-57 |
| 作者姓名： | 汪海波 刘大川 汪海婴 崔邦梓 谢笔钧 |
| 作者单位： | 1. 武汉工业学院食品学院,武汉,430023;华中农业大学食品学院,武汉,430000 2. 武汉工业学院食品学院,武汉,430023 3. 华中科技大学同济医学院,武汉,430000 4. 华中农业大学食品学院,武汉,430000 |
| 摘 要： | 目的:探讨燕麦β-葡聚糖(Oglu)对四氧嘧啶致糖尿病大鼠(DM)胰岛功能的影响。方法:大鼠腹腔注射四氧嘧啶建立DM模型后灌胃Oglu,剂量200mg/kgbw,连续14d,实验结束后测定大鼠血清胰岛素和C肽含量,并取大鼠胰腺,观测胰岛细胞组织形态学变化、分析胰岛β细胞凋亡和p53、bcl-2基因表达。结果:经Oglu治疗后,DM大鼠血清胰岛素含量(29.34±5.1)和C肽含量(1.89±0.28)较治疗前(16.8±4.9和1.32±0.31)明显增高(P<0.01),胰腺细胞团由1～2个增加到2～4个,且受损胰岛细胞有明显好转迹象;胰岛bcl-2基因表达增强,p53基因表达受抑,同时胰岛β细胞的凋亡进程得到缓解。结论:Oglu对大鼠受损的胰岛细胞有一定修复作用,可促进bcl-2和抑制p53基因表达。 |
| 关 键 词： | 燕麦β-葡聚糖 糖尿病 胰岛功能 |
| 文章编号： | 0512-7955（2006）01-0054-04 |
| 收稿时间： | 2005-06-07 |
| 修稿时间： | 2005-06-07 |
EFFECT OF OAT β -GLUCAN ON PANCREATIC FUNCTION IN DIABETIC RATS |
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| WANG Hai-bo,LIU Da-chuan,WANG Hai-ying,CUI Bang-zi,XIE Bi-jun. EFFECT OF OAT β -GLUCAN ON PANCREATIC FUNCTION IN DIABETIC RATS[J]. Acta Nutrimenta Sinica, 2006, 28(1): 54-57 | |
| Authors: | WANG Hai-bo LIU Da-chuan WANG Hai-ying CUI Bang-zi XIE Bi-jun |
| Abstract: | Objective: To study the effect of oat glucan on pancreatic function in diabetic rats. Method:The diabetic rats induced by alloxan were given oatβ-glucan (200 mg/kg bw) for 14 d and then the serum insulin , C peptides were determined. The morphology and apoptosis of β cells, and expression of p53 and bcl-2 genes were observed. Results: By giving oatβ-glucan , the serum insulin and C peptide were increased significantly in diabetic rats (P<0.01), and the pancreatic cells began to restore. The expression of bcl-2 genes were boosted up and the p53 genes were repressed. Conclusion: Oatβ-glucan could restore the function of βcells. The mechanism was associated with inhibition of p53 gene and enhanced expression of bcl-2 gene. |
| Keywords: | oatβ-glucan diabetes pancreatic functions |
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