Anomalous responses to histamine stimulation of guinea-pig oesophageal muscularis mucosae. |
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| Authors: | E Barocelli M Chiavarini G Morini V Ballabeni T Vitali C Silva M Impicciatore |
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| Institution: | Institute of Pharmacology and Pharmacognosy, Department of Pharmacy, University of Parma, Italy. |
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| Abstract: | The incomplete tachyphylaxis of the contractile response to the H1-stimulants observed on guinea-pig oesophageal muscularis mucosae seems to be H2- and H3-antagonist as well as atropine- and tetrodotoxin-resistant. Lidocaine and eserine partially prevented this process probably by a mechanism independent of their main activity. The dualistic antagonism exerted by mepyramine and methysergide on reproducible histamine responses could be explained by a kinetic condition of "hemi-equilibrium state" together with changes of drug-receptor interaction and by non-specific properties of methysergide. On the whole, the present data indicate that the role of histamine in this tissue has still to be defined. |
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