| 螺旋藻对DMBA/巴豆油诱导小鼠皮肤肿瘤预防作用的研究 |
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| 引用本文： | 葛化冰,付招娣,王建滨,孙正. 螺旋藻对DMBA/巴豆油诱导小鼠皮肤肿瘤预防作用的研究[J]. 北京口腔医学, 2004, 12(3): 135-137,140 |
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| 作者姓名： | 葛化冰 付招娣 王建滨 孙正 |
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| 作者单位： | 100050,首都医科大学附属北京口腔医院牙周黏膜科,北京;100050,中国医学科学院、中国协和医科大学药物研究所,北京 |
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| 基金项目： | 北京市中医药管理局科研项目 |
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| 摘 要： | 目的:评价螺旋藻在癌症发生起始和促进阶段的防癌、抗癌作用.方法:采用经典的DMBA/巴豆油诱导小鼠皮肤乳头状瘤形成的2阶段致癌模型,观察和评价螺旋藻在不同阶段的抗化学致癌作用.结果:螺旋藻对DMBA/巴豆油诱发的小鼠皮肤乳头状瘤的形成在始发阶段和促癌阶段均有明显抑制作用,并可推迟小鼠皮肤乳头状瘤的发生.结论:螺旋藻具有较强的癌症化学预防作用.
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| 关 键 词： | 螺旋藻 皮肤肿瘤 化学预防 |
| 文章编号： | 1006-673X(2004)03-0135-03 |
EFFECTS OF SPIRULINA PLATENSIS ON THE PREVENTION OF CHEMICALLY INDUCED SKIN TUMORS OF MICE |
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| GE Hua-bing et al.Faculty of Stomatology,Capital University of Medical Sciences,Beijing. EFFECTS OF SPIRULINA PLATENSIS ON THE PREVENTION OF CHEMICALLY INDUCED SKIN TUMORS OF MICE[J]. Beijing Journal Of Stomatology, 2004, 12(3): 135-137,140 |
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| Authors: | GE Hua-bing et al.Faculty of Stomatology Capital University of Medical Sciences Beijing |
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| Affiliation: | GE Hua-bing et al.Faculty of Stomatology,Capital University of Medical Sciences,Beijing 100050 |
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| Abstract: | Objective:To evaluate the anti-carcinogeneic effects of spirulina platensis in initiation and promotion stage of carcinogenesis.Methods:The mouse skin papilloma model induced by 7,12-dimethylbenz(a)anthraene(DMBA)/croton oil was established,which was a classical two-stage cancer model,to observe and evaluate the anti-carcinogeneic activity of spirulina platensis.Results:Oral administration of spirulina platensis could prolong latent period of tumor occurrence,decrease the incidence of papilloma and reduce tumor number in dose-dependent manner.Conclusion:Spirulina platensis can significantly inhibit the mouse skin papilloma formation and is an effective agent for cancer chemoprevention. |
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| Keywords: | Spirulina platensis Skin papilloma Chemoprevention |
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