睾丸原发性非霍奇金淋巴瘤病理特征分析

目的探讨睾丸原发性非霍奇金淋巴瘤的临床表现、病理形态学特征、免疫表型、诊断及鉴别诊断。方法对6例睾丸原发性淋巴瘤进行形态学和免疫组化染色观察,结合文献对其临床病理特点进行分析。结果患者年龄62-75岁。主要症状为睾丸无痛性肿大。经免疫组化证实6例均为非霍奇金弥漫性大B细胞性淋巴瘤。其中4例为中心母细胞为主型,1例为中心母细胞-中心细胞混合型,1例为B免疫母细胞型。免疫组化染色肿瘤细胞CD20、CD45RO、CD79a均阳性,CD3、CD45Ra、CD30、PLAP均阴性。结论睾丸原发性恶性淋巴瘤中老年人多见,出现睾丸弥漫性肿大,以非霍奇金弥漫性大B细胞性淋巴瘤为主,正确的病理诊断对指导临床治疗和判断预后有重要的作用。

The clinicopathological characteristics with testicular primary non-Hodgkin''''s lymphoma

Objective To investigate the clinical manifestation,pathological features,immunohistochemical,diagnosis and differential diagnosis in the testicular primary malignant non-Hodgkin's lymphoma.Methods The morphological and immunohistochemistry of testis in six cases with primary lymphoma were observed and literature and the clinical features were analyzed.Results Patients' age was from 62-75 years old and the main symptom was of painless testicular enlargement.Six cases were non-Hodgkin's diffuse large B-cell lymphoma by immunohistochemical staining.4 cases of them were centroblastic lymphoma,one case was mixed of immunoblastic lymphoma and another one was of B-cell lymphoma.Immunohistochemical staining for CD20,CD45RO and CD79a were positive;and CD3,CD45Ra,CD30,PLAP were negative.Conclusion Primary lymphoma of the testis is mostly in middle-aged and the elder.Most cases are non-Hodgkin's diffuse large B-cell lymphoma in these diffuse swelling of testicles.Precise pathological diagnosis can play important role for clinical treatment and prognosis.