Myelodysplasia and acute myeloid leukemia occurring after autologous bone marrow transplantation for lymphoma |
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Authors: | S. Thomas Traweek Marilyn L. Slovak Auayporn P. Nademanee Russell K. Brynes Joyce C. Niland Stephen J. Forman |
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Affiliation: | a Department of Pathology, Duke University Medical Center, Durham. North Carolina and The James Irvine Center for the study of Leukemia and Lymphoma and the Department of Cytogenetics. Division of Pathology. The Department of Hematology and Bone Marrow Transplantation, Division of Medicine, and The Department of Biostatistics, City of Hope National Medical Center, Duarte California, USA |
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Abstract: | Secondary hematopoietic disease manifesting as acute myeloid leukemia, myelodysplastic syndrome or clonal karyotypic abnormalities, has been recently recognized as a relatively frequent and potentially serious complication of autologous bone marrow transplantation for both Hodgkin's disease and non-Hodgkin's lymphoma. The available evidence suggests the disease results primarily from repeated exposure of the host stem cells to therapeutic agents before the time of transplant, but a conspiratory role for the transplantation procedure itself cannot be entirely excluded. Strategies to decrease the incidence of secondary hematopoietic disease include earlier stem cell harvest and/or transplantation, and the performance of screening karyotypic studies on the bone marrow prior to autologous grafting. |
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Keywords: | autologous bone marrow transplantation acute myeloid leukemia myelodysplastic syndrome chromosome abnormalities |
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