| Nogo-A的研究进展 |
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| 引用本文： | 姜俊杰,张树栋,刘云鹏,洪焕玉,王守彪,夏玉军. Nogo-A的研究进展[J]. 医学分子生物学杂志, 2004, 1(3): 178-181 |
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| 作者姓名： | 姜俊杰 张树栋 刘云鹏 洪焕玉 王守彪 夏玉军 |
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| 作者单位： | 烟台市烟台山医院骨科,山东省,烟台市,264001;青岛大学医学院解剖学教研室,青岛市,266021 |
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| 摘 要： | Nogo-A是近年来人们在中枢神经系统髓磷脂中研究发现的一种抑制轴突生长的蛋白。现已证明,Nogo蛋白是网状蛋白家族的第四个成员,是一种跨膜蛋白。目前已证实其在体外培养时有很强的神经轴突生长抑制活性。Nogo-A的发现将使神经系统损伤的治疗产生革命性的进步。
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| 关 键 词： | Nogo-A 神经损伤 抑制蛋白 |
| 修稿时间： | 2003-12-17 |
Advances in the Study of Nogo-A |
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| JIANG Junjie,ZHANG Shudong,LIU Yunpeng,HONG Huanyu,WANG Shoubiao,XIA Yujun. Advances in the Study of Nogo-A[J]. Journal of Medical Molecular Biology, 2004, 1(3): 178-181 |
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| Authors: | JIANG Junjie ZHANG Shudong LIU Yunpeng HONG Huanyu WANG Shoubiao XIA Yujun |
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| Affiliation: | JIANG Junjie,ZHANG Shudong,LIU Yunpeng,HONG Huanyu,WANG Shoubiao,XIA YujunDepartment of Orthopaedics,Yantaishan Hospital,Yantai,Shandong,264001,ChinaDepartment of Anatomy,Medical College of Qingdao University,Qingdao,266021,China |
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| Abstract: | Nogo-A is a recently identified inhibitory protein found in myelin of central nervous system. It has been confirmed that Nogo-A is a potent inhibitor of neurite outgrowth. It has been demonstrated that Nogo protein is a member of a family of proteins called the Reticulon family and is a transmembrane protein. Experiments showed that it had strong inhibitory effect on neurite growth. The studies of Nogo-A have brought about encouraging results in the researches of CNS regeneration. This article reviews the advances in the study of Nogo-A in recently years. |
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| Keywords: | Nogo-A nervous injury inhibitory protein |
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