Electron microscopic and immunohistochemical studies of gastrointestinal stromal tumors |
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Authors: | J. Yamaguchi Norimasa Sawada Hirotoshi Tobioka Reiko Takakuwa Tomoko Goto Yuji Sakuma Tatsuru Ikeda Masaaki Satoh Michio Mori |
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Affiliation: | (1) Department of Pathology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark;(2) Faculty of Medical Laboratory Science, University College Oeresund, Faelledvej 12, 2200 Copenhagen N, Denmark;(3) Department of Virus, Hormones and Cancer, Danish Cancer Society, Copenhagen, Denmark;(4) Department of Rheumatology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark;(5) Department of Biology, University of California, San Diego, La Jolla, San Diego, CA, USA |
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Abstract: | Sixteen gastrointestinal stromal tumors (GISTs) were studied by immunohistochemical analysis and an ultrastructural procedure. The tumor locations were as follows: esophagus (2), stomach (7), small intestine (3), and large intestine (4). Four of the lesions were classified as malignant, 2 as borderline, and 10 as benign. On the basis of the immunohistochemical analysis, the tumors were classified as follows: 1 as myogenic type, 2 as Schwann cell type, 8 as Cajal cell type (including 2 gastrointestinal autonomic nerve tumors, GANTs), and 5 as mixed-cell type. In each subtype the phenotype was compared to the ultrastructural findings. Myogenic and Schwann cell type revealed ultrastructurally smooth muscle differentiation and schwannian tumor. All 8 tumors of the Cajal cell type revealed interdigitating cytoplasmic processes with occasional clusters of filopodia. Two tumors were subdivided as GANT. Five tumors of mixed-cell type were composed of a mixture of cells with variable myogenic features or variable neural differentiation. We confirmed in this study that immunohistochemical analysis reflected electron microscopic findings. |
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