| 吡噻硫酮治疗动物日本血吸虫病的初步研究 |
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| 引用本文： | 吴玲娟,宣尧仙,李振发,李思温,高柏生. 吡噻硫酮治疗动物日本血吸虫病的初步研究[J]. 中国医药工业杂志, 1988, 0(2) |
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| 作者姓名： | 吴玲娟 宣尧仙 李振发 李思温 高柏生 |
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| 作者单位： | 浙江医学研究院寄生虫病研究所 杭州 |
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| 摘 要： | 报告了吡噻硫酮对几种实验动物日本血吸虫病的疗效。口服给药,小鼠1g/(kg·d)×5,治愈率为100%,半数治愈剂量(CD_(50))为475mg/(kg·d)×5,家兔150mg/(kg·d)×4,减虫率为80.1%,治愈1/3。该药对犬血吸虫病无效。小鼠的急性 LD_(50)>10g/kg。
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| 关 键 词： | 吡噻硫酮 日本血吸虫病 治疗 |
PRELIMINARY ANIMAL TESTS ON SCHISTOSOMICIDE OLTIPRAZ |
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| WU Ling-Juan XUAN Yao-Xian LI Zhen-Fa LI Si-Wen GAO Bai-Shen. PRELIMINARY ANIMAL TESTS ON SCHISTOSOMICIDE OLTIPRAZ[J]. , 1988, 0(2) |
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| Authors: | WU Ling-Juan XUAN Yao-Xian LI Zhen-Fa LI Si-Wen GAO Bai-Shen |
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| Abstract: | Oltipraz was used to treat animals infected with Schistosomaiaponicum.The acute LD_(50) for mice was 10g/kg orally.Infected mice received1g/(kg.d)for 5 consecutive days,the rate of cure was 100%.The CD_50 in micewas 475mg/(kg.d)for 5 consecutive days.However,oltipraz had no obviouseffect in treating infected rabbits and dogs. |
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| Keywords: | oltipraz Schistosomiasis japonica treatment |
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