Fatal pulmonary thromboembolism after a second course of high-dose chemotherapy with autologous peripheral blood stem cell transplantation |
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Authors: | Kounami Shinji Aoyagi Noriyuki Nakayama Keiko Yoshiyama Megumi Boshi H Sakiyama Michiyo Takeuchi Takeshi Yoshikawa Norishige |
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Institution: | Department of Pediatrics, Wakayama Medical University, Kimiidera Wakayama City, Japan |
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Abstract: | We describe a 4-yr-old boy with an occult primitive neuroectodermal tumor, who suffered fatal PTE after a second course of HDC with autologous PBSCT. On day + 52 after a second PBSCT, he was admitted because of respiratory distress. Respiratory failure rapidly progressed and he died within 4 days. The diagnosis of PTE was confirmed by a lung perfusion study with technetium-99m macroaggregated albumin, but too late to allow treatment. Although rare, PTE must be recognized as an important differential diagnosis when respiratory symptoms are observed after HDC with PBSCT. |
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Keywords: | pulmonary thromboembolism high-dose chemotherapy peripheral blood stem cell transplantation |
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