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Decreased sensitivity of neurons in the basolateral amygdala to dopamine and noradrenaline iontophoresis after a kindling stimulus |
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| Authors: | R Spehlmann K Norcross |
| Affiliation: | 1. Neurology Service, VA Lakeside Medical Center, Chicago, Illinois, USA;2. Department of Neurology, Northwestern University, Chicago, Illinois, USA;3. Department of Pharmacology, Northwestern University, Chicago, Illinois, USA;4. the Department of Neurology, University of Texas Medical Branch, Galveston, Texas 60611 USA |
| Abstract: | The depressant effects of iontophoretically applied dopamine and noradrenaline on glutamate-induced neuronal firing in the amygdaloid complex of cats were significantly reduced 1 and 2 h after induction of a local epileptiform afterdischarge of the kind used in kindling. Neuronal excitation by glutamate and depression by GABA were not significantly changed. This suggests that kindling is associated with a reduction of the inhibitory effects of endogenous catecholamines. |
| Keywords: | AC amygdala complex DA dopamine NA norepinephrine GABA aminobutyric acid |
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