| 对14个厂家盐酸二甲双胍片溶出度的考察 |
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| 引用本文： | 余继英,许民,陈旭光,孙世明. 对14个厂家盐酸二甲双胍片溶出度的考察[J]. 中国药房, 2003, 14(1): 41-42 |
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| 作者姓名： | 余继英 许民 陈旭光 孙世明 |
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| 作者单位： | 四川省人民医院药剂科,成都市610072 |
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| 摘 要： | 目的 :考察市售不同厂家盐酸二甲双胍片的溶出度。方法 :采用转篮法对14个厂家的盐酸二甲双胍片进行体外溶出度测定 ,并进行溶出参数方差分析。结果 :14个厂家产品的体外溶出度均符合《中国药典》2000年版的规定 ,但溶出参数各不相同。结论 :经统计学处理 ,不同厂家盐酸二甲双胍片抽检品的溶出参数有显著性差异 (P<0 01)。
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| 关 键 词： | 盐酸二甲双胍片 溶出度 紫外分光光度法 |
| 文章编号： | 1001-0408(2003)01-0041-02 |
| 修稿时间： | 2001-11-20 |
Study on the Dissolubility of Metformin Hydrochloride Tablets From 14 Pharmaceutical Factories |
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| YU Jiying,XU Min,CHEN Xuguang,SUN Shiming. Study on the Dissolubility of Metformin Hydrochloride Tablets From 14 Pharmaceutical Factories[J]. China Pharmacy, 2003, 14(1): 41-42 |
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| Authors: | YU Jiying XU Min CHEN Xuguang SUN Shiming |
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| Abstract: | OBJECTIVE:To investigate the dissolubility of commercial metformin hydrochloride tablets from different manufactories.METHODS:The in vitro dissolubility of 14 kinds of commercial metformin hydrochloride tablets was determined by basket method and the dissolution parameters were analyzed with variance analysis method.RESULTS:The in vitro dissolubility of 14 kinds of metformin hydrochloride tablets fitted to the request of ChP2000,but the dissolution parameters were different.CONCLUSION:The statistical results indicate that there are significant differences between products from different factories(P<0.01). |
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| Keywords: | metformin hydrochloride tablet dissolubility UV-spectrophotometry |
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