Role of altered immune cells in liver diseases: a review |
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| Authors: | Braira Wahid Amjad Ali Shazia Rafique Komal Saleem Muhammad Waqar Muhammad Wasim Muhammad Idrees |
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| Institution: | 1. Centre for Applied Molecular Biology (CAMB), 87-West Canal Bank Road Thokar Niaz Baig, University of the Punjab, Lahore, Pakistan;2. Genome Centre for Molecular Based Diagnostics and Research, Al-Sudais Plaza Abdalian Cooperative Society, Lahore, Pakistan;3. Department of Medicine, Khyber Teaching Hospital Peshawar KPK, Pakistan;4. Division of Molecular Virology and Diagnostics Center of Excellence in Molecular Biology (CEMB), 87-West Canal Bank Road Thokar Niaz Baig, University of the Punjab, Lahore, Pakistan;5. Vice Chancellor Hazara University Mansehra, Pakistan |
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| Abstract: | Immune cells play an important role in controlling liver tumorigenesis, viral hepatitis, liver fibrosis and contribute to pathogenesis of liver inflammation and injury. Accumulating evidence suggests the effectiveness of natural killer (NK) cells and Kupffer cells (KCs) against viral hepatitis, hepatocellular damage, liver fibrosis, and carcinogenesis. Activation of natural killer cells provides a novel therapeutic strategy to cure liver related diseases. This review discusses the emerging roles of immune cells in liver disorders and it will provide baseline data to scientists to design better therapies for treatment. |
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| Keywords: | Liver Cirrhosis NK Cells Dendritic cells Hepatic stellate cells Hígado Cirrosis Células NK Células dendríticas Células de Kupffer |
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