血必净对老年脓毒症患者多脏器功能的保护作用

目的:探讨血必净对老年脓毒症多脏器功能保护的机制和疗效。方法:将70例老年脓毒症患者随机分为治疗组和对照组。治疗组加用血必净100mL静脉点滴,每天2次,共7d,其余治疗2组相同。于治疗前和治疗后第8天测定血浆肿瘤坏死因子-!(TNF-")和白细胞介素-6(IL-6)等炎性介质及血浆生化指标。结果:2组患者治疗后TNF-α和IL-6均较治疗前下降,治疗组较对照组下降更显著(P均<0.05);2组血浆丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、肌酐(Cr)和尿素氮(BUN)均较治疗前明显降低(P均<0.01),且治疗组前三项指标较对照组下降明显;2组血浆乳酸脱氢酶(LDH)、肌酸激酶(CK)及其同工酶(CK-MB)均较治疗前明显降低(P均<0.01),治疗组较对照组下降更显著(P均<0.05)。结论:血必净对老年脓毒症的肝、肾、心脏功能有较好的保护作用。

The Protective Effect of Xue-bi-jing on Multiple Organ Function in Eldly Patiens with Sepsis Syndrome

Objective:To investigate the protective mechanism and efficacy of Xue Bijing on multiple organ function in eldly patients with sepsis syndrome.Methods:seventy eldly patients with sepsis syndrome were randomly divided into Xue Bijing group and control group.100mL Xue Bijing were given(iv,q12 h) for 7 days in Xue Bijing group,The same treatment was given to two groups.Tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and other plasma biochemistrial indexes were determined before the treatment and 8 days after the treatment.Results:After the treatment.the level of TNF-α and IL-6 significantly decreased in two groups,and the decrease was more obvious in two groups(P <0.05);plasma alanine aminotransferase(ALT),aspartate aminotransferase(AST),creatinine(Cr),blood urea nitrogen(BUN)and lactate dehydrogenase(LDH),creatine kinase(CK),and MB isoenzyme of creatine kinase(CK-MB)were significantly decreased in two groups after the treatment(P <0.01),but the decreases of all these indexes were more marked in Xue Bijing group(P < 0.05).Conclusion:Xue Bijing has beneficial effects on the protection of liver,renal and heart function in eldly patients with sepsis syndrome.