| 高血压病患者冠状动脉内皮功能的超声心动图研究 |
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| 引用本文： | 邓又斌,汪道文,马春桃,黎春雷,杨好意,常青,潘敏. 高血压病患者冠状动脉内皮功能的超声心动图研究[J]. 中国医学影像技术, 2001, 17(9): 860-862 |
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| 作者姓名： | 邓又斌 汪道文 马春桃 黎春雷 杨好意 常青 潘敏 |
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| 作者单位： | 1. 华中科技大学同济医学院附属同济医院超声影像科
2. 华中科技大学同济医学院附属同济医院心内科 |
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| 摘 要： | 目的应用超声心动图评价高血压病患者冠状动脉内皮功能及血管紧张素Ⅱ1型受体(AT1)拮抗剂对冠状动脉内皮功能的影响.方法研究对象包括24例轻至中度原发性高血压病患者和24例健康对照组.分别于AT1拮抗剂(Losartan或Telmisartan)服用前和服用12周后应用超声心动图测量冷加压试验和硝酸甘油诱导的冠脉左主干内径变化.结果冷加压试验诱导的冠脉左主干内径百分变化率在高血压病组(-4.3±8.7%)显著低于对照组(10.5±3.9%,P＜0.0001).服用AT1拮抗剂后,高血压病组冷加压试验诱导的冠脉左主干内径百分变化率(13.7±8.0%)明显高于服用前(-4.3±8.7%,P＜0.0001),冷加压试验诱发的冠状动脉左主干内径百分变化率在14例血压控制满意的患者中(从-5.7±7.7%变为14.1±8.8%,P＜0.0001)和10例血压控制不满意的患者中(从-2.3±10.0%变为13.1±7.0%,P=0.002)均得到改善.高血压病组舌下含服硝酸甘油诱导的冠脉左主干内径百分变化率在治疗前后无明显差异(23.2±14.4%比27.2±13.5%,P=0.2).结论本研究证明轻至中度原发性高血压病患者冠状动脉内皮功能受损,经AT1拮抗剂治疗后,冠脉左主干可恢复对冷加压试验的正常反应,而且此种效应不依赖于血压是否得到控制.
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| 关 键 词： | 冠状动脉内皮功能 冷加压试验 高血压 血管紧张素Ⅱ拮抗剂 超声心动图描记术 |
| 文章编号： | 1003-3289(2001)09-0860-03 |
| 收稿时间： | 2001-05-25 |
| 修稿时间： | 2001-05-25 |
Echocardiographic Evaluation of Coronary Endothelial Function in Patients with Essential Hypertension |
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| DENG You-bin,WANG Dao-wen,MA Chun-tao,LI Chun-lei,YANG Hao-yi,CHANG Qing and PAN Min. Echocardiographic Evaluation of Coronary Endothelial Function in Patients with Essential Hypertension[J]. Chinese Journal of Medical Imaging Technology, 2001, 17(9): 860-862 |
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| Authors: | DENG You-bin WANG Dao-wen MA Chun-tao LI Chun-lei YANG Hao-yi CHANG Qing PAN Min |
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| Affiliation: | Department of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;Department of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;Department of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;Department of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;Department of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;Department of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China |
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| Abstract: | Objective We attempted to evaluate the coronary endothelial function and the effects of angiotensin II type 1 receptor (AT1) antagonists on coronary endothelial function in patients with essential hypertension using echocardiography. Methods
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| Keywords: | Coronary endothelial function Cold pressor test Hypertension Angiotensin antagonist Echocardiography |
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