| 前列腺癌内分泌治疗后无进展生存期的影响因素分析 |
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| 引用本文： | 管杨波,章益芬,文航,周祀侨,戴玉田. 前列腺癌内分泌治疗后无进展生存期的影响因素分析[J]. 中华男科学杂志, 2009, 15(9): 801-805 |
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| 作者姓名： | 管杨波 章益芬 文航 周祀侨 戴玉田 |
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| 作者单位： | 1. 南京医科大学鼓楼临床医学院,泌尿外科,江苏,南京,210008
2. 南京医科大学鼓楼临床医学院,病理科,江苏,南京,210008 |
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| 摘 要： | 目的:前列腺癌内分泌治疗后发现进展速度存在较大差异,为了改善其预后,本文探讨前列腺癌内分泌治疗后无进展生存期的影响因素。方法:回顾性分析116例接受内分泌治疗的前列腺癌患者的临床病理资料,对各临床病理因素之间进行Spearman等级相关分析,对各临床病理因素分别进行单因素分析(log-rank检验),应用Cox比例风险模型进行多因素统计分析。结果:Cox比例风险模型发现有统计学意义的因素为Gleason评分(P<0.01)和临床分期(P<0.01)。Gleason评分每增加1个单位量,内分泌治疗后发生进展的风险将增加为原来的2.126倍,临床分期每增加1个单位量,内分泌治疗后发生进展的风险将增加为原来的6.625倍。治疗前的血清总PSA水平分别与临床分期(P<0.01)、Gleason评分(P<0.01)都存在等级相关。结论:临床分期和Gleason评分是影响前列腺癌内分泌治疗后无进展生存期的重要因素。
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| 关 键 词： | 前列腺癌 内分泌治疗 无进展生存期 |
Factors Influencing the Progression-flee Survival Time of Prostate Cancer Patients After Endocrine Therapy |
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| GUAN Yang-bo,ZHANG Yi-fen,WEN Hang,ZHOU Si-qiao,DAI Yu-tian. Factors Influencing the Progression-flee Survival Time of Prostate Cancer Patients After Endocrine Therapy[J]. National journal of andrology, 2009, 15(9): 801-805 |
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| Authors: | GUAN Yang-bo ZHANG Yi-fen WEN Hang ZHOU Si-qiao DAI Yu-tian |
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| Affiliation: | GUAN Yang-bo , ZHANG Yi-fen, WEN Hang , ZHOU Si-qiao, DAI Yu-tian( 1. Department of Urology, 2. Department of Pathology, Drum Tower School of Clinical Medicine, Nanjing Medical University, Nanfing, Jiangsu 210008, China) |
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| Abstract: | Objective:The progression of prostate cancer (PCa) after endocrine therapy varies widely in different PCa patients. This study aims to analyze the factors that influence the progression-free survival time of PCa patients after endocrine therapy in an attempt to improve the prognosis of the disease. Methods: We reviewed the clinicopathological data of 116 cases of prostate cancer treated by endocrine therapy,analyzed the clinicopathological factors that influence the progression-free survival time of PCa pat... |
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| Keywords: | prostate cancer endocrine therapy progression-free survival time |
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