| 白细胞介素-4基因-590C／T多态性与慢性牙周炎的相关性研究 |
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| 引用本文： | 刘激,肖立民,轩东英,章锦才,黄雁红,谢宝仪.白细胞介素-4基因-590C／T多态性与慢性牙周炎的相关性研究[J].广东牙病防治,2011,19(5):257-259. |
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| 作者姓名： | 刘激 肖立民 轩东英 章锦才 黄雁红 谢宝仪 |
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| 作者单位： | 南方医科大学附属口腔医院;广东省口腔医院牙体牙髓科; |
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| 摘 要： | 目的研究白细胞介素-4（interleukin-4，IL-4）基因-590C／T多态性与慢性牙周炎易感性的关系。方法采用病例对照试验设计，聚合酶链反应一限制性内切酶片段长度多态性基因分析方法，比较104例慢性牙周炎患者（慢性牙周炎组）和106例牙周健康者（健康对照组）IL-4基因-590位点基因型和等位基因分布特点。结果IL-4基因-590位点C、T等位基因频率（X2=0．771，P=0．380）及基因型频率（X2=1．904，P=0．386）在两组间分布差异无统计学意义。结论IL-4基因-590位点的多态性与汉族人群慢性牙周炎的易感性无明显相关性。
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| 关 键 词： | 慢性牙周炎 白细胞介素-4 基因多态性 慢性牙周炎 白细胞介素-4 多态现象 遗传学 |
Association Between IL-4-590C/T Gene Polymorphism and Chronic Periodontitis |
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| LIU Wei,XIAO Li-min,XUAN Dong-ying,et al..Association Between IL-4-590C/T Gene Polymorphism and Chronic Periodontitis[J].Journal of Dental Prevention and Treatment,2011,19(5):257-259. |
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| Authors: | LIU Wei XIAO Li-min XUAN Dong-ying |
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| Institution: | LIU Wei,XIAO Li-min,XUAN Dong-ying,et al.The Affiliated Stomatological Hospital of Southern Medical University & Guangdong Provincial Stomatological Hospital,Guangzhou 510280,China |
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| Abstract: | Objective To investigate the association between IL-4-590C/T gene polymorphism and the occurrence of chronic periodontitis.Methods The genotypes of IL-4 of 104 patients with chronic periodontitis and 106 healthy controls were analyzed by polymerase chain reaction-restriction fragment length polymorphisms(PCR-RFLP) in a case-control study.Distributions of single alleles and genotypes were analyzed by the chi-square test.Results No significant difference in the allele and genotype frequencies of IL-4-590 betw... |
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| Keywords: | Chronic periodontitis Interleukin-4 Gene polymorphism |
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