重症肌无力患者CD5+B细胞的变化 |
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引用本文: | 韩钊,徐文桢,刘鸣,魏于全,雷松. 重症肌无力患者CD5+B细胞的变化[J]. 中国免疫学杂志, 2000, 16(3): 160-162 |
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作者姓名: | 韩钊 徐文桢 刘鸣 魏于全 雷松 |
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作者单位: | 1. 温州医学院附一院神经科,温州,325000 2. 华西医大附一院神经科,成都,610041 3. 华西医大肿瘤生物治疗中心,成都,610041 |
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摘 要: | 目的:研究CD^+B细胞在重症肌无力(MC)发病中的作用。方法L:采用免疫荧光双标记技术和流式细胞仪对39例MG患者和18例健康对照者周围血中CD5^+细胞(CD5^+CD19^+)的百分率进行测定,同时用ELISA间接法检测MC患者血清中AchRab。结果:在MG患者周围血CD5^+B细胞百分率显著高于对照组,而且在血清AchRab阳性和阴性MG中CD5^+B细胞均明显高于对照组;但在血清Ach
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关 键 词: | 重症肌无力 乙酰胆碱受体 抗体 CD5^+B细胞 |
Change of CD5+B cell in patients with myasthenia gravis |
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Abstract: | Objective: To study the role of CD5 B cells in the pathogenic mechanism of myasthenia gravis(MG). Methods: The percentages of CD5 B cell(CD5 CD19 ) in 39 patients with MG and 18 healthy control were determined using immunofluorescence double staining and flow cytometry; the AchRab of serum in MG patients were determined by indirect ELISA methods.Results: The percentages of CD5 B cell was significant increase in MG patients as compared with healthy controls, moreover, the percentages of CD5 B cell in serum AchRab positive and serum AchRab negative MG patients were both higher than that of healthy controls, but the percentages of CD5 B cell have no significant differ between serum AchRab positive and serum AchRab negative MG patients.Conclusion: CD5 B cell may play a pathogenic role in the development of MG, there is no significant correlation between AchRab production and CD5 B lymphocytes ; CD5 B cell might contribute to the pathogenesis of AchRab negative MG. |
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Keywords: | Myasthenia Gravis Acetylcholine receptor antibody CD5 B cell Flow cytometry |
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