诺和锐30治疗2型糖尿病的疗效观察

目的：观察比较诺和锐30和诺和灵30R治疗2璎糖尿病的临J术疗效。方法：将64例2型糖尿病患者随机分成诺和锐30组和诺和灵30R组，治疗12周后，观察两种不同治疗方案患者空腹血糖（FBG）、餐后2h血糖（2hPBG）、糖化血红蛋白（HbA1c）、体质指数（BMI）、胰岛素剂量变化及低血糖发生的情况。结果：（1）两组治疗后FBG、2hPBG、HbA1c均明显下降（P〈0．01），但诺和锐30组餐后血糖、糖化血红蛋白下降更明显（P〈0．05）；（2）诺和锐30组低血糖发生牢明显低于诺和灵30R组（P〈0．05）；（3）诺和锐30组胰岛素剂量、体质指数增加幅度高于诺和灵30R组，但差异无统计学意义（P〉0．05）。结论：诺和锐30能更好地降低2型糖尿病的血糖水平．尤其是餐后血糖，且不增加低血糖的风险。

The effects of insulin aspart 30 injection in treatment of type 2 diabetes

Objective: To evaluate the effect of insulin aspart 30 injection and novolin 30R prnfill in treament of type 2 diabetes(T2DM).Method: Sixty-four patients with T2DM were randomly divided into two groups: insulin aspart 30 injection group and novolin 30R prnfill group.After 12 weeks,the levels of fasting plasma glucose(FBG),2 hours postprandial glucose(2 hPBG),glycosylated hemoglobin A1c(HbA1c),body-mass index(BMI),insulin dosages,frequency of hypoglycemia were compared before and after the treament.Results:(1) FBG,2 hPBG,HbA1c were significantly decreased in two groups(P<0.01),but insulin aspart 30 injection group was associated with a significantly lower 2 hPBG,HbA1c than novolin 30R prnfill group(P<0.05).(2) The frequency of hypoglycemia of insulin aspart 30 injection group was significantly lower than that of novolin 30R prnfill group(P<0.05).(3) The level of insulin dosages and body-mass index of insulin aspart 30 injection groups was higher than that of novolin 30R prnfill groups(P>0.05).Conclusion: Insulin aspart 30 injection can effectively decrease 2 hour postprandial glucose and frequency of hypoglycemia in type 2 diabetic patients.