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Alterations in lymphocyte subsets in blood may predict resectability in carcinoma of cardia or oesophagus |
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| Authors: | ystein H Bentdal Stig S Frland Vidar Bosnes Anstein Bergan Odd Sreide Audun Flatmark |
| Institution: | a Department of Surgery, Rikshospitalet, The National Hospital, University of Oslo, 0027, Oslo, Norway b Department of Medicine, Rikshospitalet, The National Hospital, University of Oslo, 0027, Oslo, Norway c Institute of Transplantation Immunology, Rikshospitalit, The National Hospital, University of Oslo, 0027, Oslo, Norway |
| Abstract: | Impaired immune responses in patients with carcinoma of cardia or oesophagus have previously been reported. However, we do not know whether resectability correlates with specific immunological variables. Immunological assessment was performed in 35 such cancer patients including measurement of total T cells (CD3+) and T cell subsets (CD4+ and CD8+), NK cells (CD16+) and B cells (CD19+) in blood. In vitro lymphocyte responses to phytohemagglutinin (PHA) separated from peripheral blood were quantitated. The numbers in peripheral blood of both total T cells (CD33+) and B lymphocytes (CD19+) were significantly lower in the inoperable patients compared to resected patients (P < 0.01). The number of NK cells (CD16+) was, however, not significantly lower in the inoperable patients compared to the patients operated for cure. Lymphocyte responses to PHA in vitro were similar in resectable and non-resectable patients, but significantly lower in inoperable patients compared to the controls (P < 0.01). In conclusion, resectability in carcinoma of cardia or oesophagus is associated with changes in both T (CD3+) and B (CD19+) cell subsets. |
| Keywords: | Lymphocyte subsets Lymphocyte responses to PHA Carcinoma of cardia or oesophagus Resectability |
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