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Receptor radionuclide therapy with 90Y-[DOTA]0-Tyr3-octreotide (90Y-DOTATOC) in neuroendocrine tumours
Authors:Lisa Bodei  Marta Cremonesi  Chiara Grana  Paola Rocca  Mirco Bartolomei  Marco Chinol  Giovanni Paganelli
Affiliation:(1) Nuclear Medicine Division, European Institute of Oncology, via Ripamonti 435, 20141 Milan, Italy;(2) Medical Physics Division, European Institute of Oncology, Milan, Italy
Abstract:Somatostatin receptors are over-expressed in many tumours, mainly of neuroendocrine origin, thus enabling treatment with somatostatin analogues. Almost a decade of clinical experience of receptor radionuclide therapy with the analogue 90Y-[DOTA]0-Tyr3-octreotide [90Y-DOTATOC] has now been obtained at a few centres of excellence. This review reports on the present state of the art of receptor radionuclide therapy and discusses new perspectives.
Keywords:90Y-DOTATOC  Neuroendocrine tumours  Receptor radionuclide therapy  Somatostatin receptors
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