种植体周围炎患者龈沟液中IL-8、IL-18的水平检测及意义

目的 探讨IL-8、IL-18在种植体周围炎龈沟液(GCF)中的表达及意义。 方法 选择2011年1月~2013年12月期间40例种植体周围炎患者为研究对象。另选择健康种植体患者40例。选择健康人群50例为健康对照组。统计3组探诊深度(PD)、龈沟出血指数(SBI)、IL-8、IL-18质量浓度,并对GCF中IL-8、IL-18质量浓度与性别、年龄、PD、SBI进行相关性分析。 结果 种植体周围炎组PD、SBI、GCF均高于健康种植体组和对照组,差异有统计学意义(P<0.01);但健康种植体组和对照组PD、SBI、GCF差异无统计学意义(P>0.05);种植体周围炎组IL-8、IL-18水平高于健康种植体组和对照组,差异有统计学意义(P<0.01),健康种植体组IL-8、IL-18水平高于对照组,差异有统计学意义(P<0.01);不同性别种植体周围炎患者GCF中IL-8、IL-18水平比较,差异无统计学意义(P>0.05);≥60岁组IL-8、IL-18水平高于<60岁组和对照组,差异有统计学意义(P<0.01),<60岁组IL-8、IL-18水平高于对照组,差异有统计学意义(P<0.01);GCF 与PD、SBI、IL-8、IL-18呈正相关(P<0.05);IL-8、IL-18与年龄、PD、SBI呈正相关(P<0.05);IL-8和IL-18之间呈正相关(P<0.05)。 结论 IL-8、IL-18在种植体周围炎患者GCF中呈高表达;GCF中IL-8、IL-18的特异性表达与种植体周围炎密切相关。

IL-8,IL-18 Expression in Peri-implant Gingival Crevicular Fluid and Clinical Significance

Objective To study IL-8,IL-18 expression in peri-implantitis gingival crevicular fluid and clinical significance. Methods Between January 2011 and December 2013, 40 patients with peri-implantitis were selected as the research object. 40 cases of healthy implant patients were selected. 50 cases of healthy people healthy were selected as the controls. The probing depth (PD), sulcus bleeding index (SBI), GCF IL-8,IL-18 mass concentration in the three groups were tested, and correlation analysis between IL-8,IL-18 mass concentration in GCF and gender, age, PD and SBI were made. Results PD and SBI, GCF in peri-implant group were higher than healthy implant group and the control group, and the difference was statistically significant (P<0.01). But the PD and SBI, GCF of healthy implant group and the control group B had no obvious difference (P>0.05); IL-8,IL-18 in peri-implant group was higher than healthy implant group and the control group, and the difference was statistically significant (P<0.01). IL-8,IL-18 levels in healthy implant group was higher than the control group, and difference was statistically significant(P<0.01). Peri-implant patients with different gender in GCF IL-8,IL-18 levels, and there was no statistically significant difference (P>0.05). IL-8,IL-18 levels of patients whose ages were 60 or higher in peri-implant group were higher than the < 60 years old group and the control group,and the difference was statistically significant (P<0.01).IL-8,IL-18 levels in the < 60 years old group were higher than the control group, and difference was statistically significant (P<0.01). The GCF was positively correlated with PD, SBI, IL-8, IL-18 (P<0.05). IL-8, IL-18 was positively correlated with age, PD, SBI (P<0.05).There was a positive correlation between IL-8 and IL-18 (P<0.05). Conclusion IL-8,IL-18 show high expression in GCF in peri-implantitis. The specific expressions of IL-8,IL-18 in GCF are closely related to peri-implantitis.