幽门螺杆菌感染与反流性食管炎相关关系分析

目的]探讨幽门螺杆菌感染与反流性食管炎的相关关系。方法]将经电子胃镜检查确诊为反流性食管炎患者90例(反流性食管炎组)及慢性胃炎患者100例(慢性胃炎组),同时经13 C尿素呼气试验法进行幽门螺杆菌检测,对比2组幽门螺杆菌感染情况。将反流性食管炎组患者根据内镜分级标准分为4级,比较各级间的幽门螺杆菌感染情况;根据临床症状程度分为轻、中、重度,比较各程度间的幽门螺杆菌感染情况。结果]反流性食管炎组幽门螺杆菌感染率(36.7%)明显低于慢性胃炎组(65.0%),差异有统计学意义(P0.01)。反流性食管炎组不同内镜分级及不同临床症状程度者间的幽门螺杆菌感染率比较,差异均无统计学意义(P0.05)。结论]幽门螺杆菌感染可能在反流性食管炎的发生过程中起保护作用,幽门螺杆菌与反流性食管炎及患者症状程度无相关性。

Correlation between Helicobacter pylori infection and reflux esophagitis

Objective]To investigate the correlation between Helicobacter pylori（Hp）infection and re-flux esophagitis（RE） .Methods]Ninety cases of patients with RE and 100 cases of patients with chronic gastritis diagnosed by electronic endoscopy were detected by 13 C-urea breath test for Hp ,and Hp infec-tion rate was compared between the two groups .RE patients were divided into four groups according to en-doscopic grading standards ,and Hp infection rate were compared among the four groups .RE patients were divided into three groups according to the degree of severity of the clinical symptoms ,and Hp infection rate were compared among the three groups .Results]Hp infection rate in RE group（36.7% ）was significantly lower than that in chronic gastritis（65.0% ） ,the difference was statistically significant（P〈0.01） .The difference of Hp infection rate in different endoscopic grading and severity of clinical symptoms was not statistically significant（P〉0 .05） .Conclusions]Hp infection may play a protective role in the pathogenesis of RE .There has no correlation between Hp and the RE symptoms .