骨碎补总黄酮对系膜增生性肾炎大鼠血清白细胞介素-6的影响

目的：观察骨碎补总黄酮对系膜增生性肾小球肾炎大鼠血IL-6及尿蛋白的影响。方法：利用免疫法制备大鼠系膜增生性肾小球肾炎模型，将大鼠分为骨碎补总黄酮组（治疗组）、病理对照组（模型组）、正常对照组，检测各组24h尿蛋白、血清IL-6，并观察肾脏病理改变。结果：模型组大鼠肾脏系膜细胞明显增生，与正常对照组比较24h尿蛋白定量及血清IL-6明显升高（P＜0．05）；治疗组大鼠肾脏系膜细胞增生减轻，24h尿蛋白、血IL-6均明显低于模型组（P＜0．05）。结论：骨碎补总黄酮能降低系膜增生性肾小球肾炎大鼠尿蛋白，降低血清IL-6水平，减轻系膜细胞增生和细胞外基质增加，延缓或减轻肾组织损伤，保护肾功能。

Effect of Rhizoma Drynariae Flavones on Levels of Serum IL -6 in Mesangial Proliferative Glomerulonephritis Rats

Objective ： To investigate the effect of Rhizoma Drynariae Flavones on levels of Serum IL - 6 and proteinuria in mesangial proliferative glomerulonephritis rats. Methods： Model of mesangial proliferative glomerulonephritis was made with immunization. Divid Waster rats into 3 groups ： Rhizoma Drynariae Flavones group（ treatment groups） ,pathological control group（ model control group） and normal control group. Each group of the level of 24 h urine protein and Serum IL - 6 were determined, And to observe the renal pathological changes. Results：In the model control group, the morphological changes in renal tissue showed that mesangial cells proliferated obviously, the level of 24 h urine protein and Serum IL -6 in the model control group were obviously higher than those in the normal control （ P 〈0.05 ）. In the treatment group, the morphological changes in renal tissue showed that mesangial ceils proliferated lightly, the level of 24 h urine protein and Serum IL - 6 in the treatment group were obviously lower than those in the model control group （P 〈0.05）. Conclusion： Rhizoma Drynariae Flavones can reduce the level of 24 h urine protein and Serum IL - 6, decrease the mesangial ceils proliferation and the extracelluar matrix accumulation, and postpones or relives the renal tissue damage. So it plays a role in protecting the renal function in rats with mesangioproliferative glomerulonephritis.